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[1]邢琳琳,国建飞,阮 昕,等.血清载脂蛋白E、降钙素原及脑钠肽对医院获得性肺炎的诊断及预后评估价值分析[J].传染病信息,2019,02:132-135.
 XING Lin-lin*,GUO Jian-fei,RUAN Xin,et al.Analysis of serum apolipoprotein E, procalcitonin and brain natriuretic peptide in the diagnosis and prognosis of hospital acquired pneumonia[J].Infectious Disease Information,2019,02:132-135.
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血清载脂蛋白E、降钙素原及脑钠肽对医院获得性肺炎的诊断及预后评估价值分析(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2019年02期
页码:
132-135
栏目:
论 著
出版日期:
2019-05-15

文章信息/Info

Title:
Analysis of serum apolipoprotein E, procalcitonin and brain natriuretic peptide in the diagnosis and prognosis of hospital acquired pneumonia
文章编号:
1007-8134(2019)02-0132-04
作者:
邢琳琳国建飞阮 昕张 萍
054000,邢台市人民医院呼吸内科(邢琳琳、阮昕、张萍),胸外科(国建飞)
Author(s):
XING Lin-lin* GUO Jian-fei RUAN Xin ZHANG Ping
Department of Respiratory Medicine, Xingtai People’s Hospital, 054000, China
关键词:
医院获得性肺炎载脂蛋白E降钙素原脑钠肽诊断价值
Keywords:
hospital acquired pneumonia apolipoprotein E procalcitonin brain natriuretic peptide diagnostic value
分类号:
R563.1
DOI:
10.3969/j.issn.1007-8134.2019.02.008
文献标识码:
A
摘要:
目的 探讨血清载脂蛋白E(apolipoprotein E, ApoE)、降钙素原(procalcitonin, PCT)及脑钠肽(brain natriuretic peptide, BNP)对医院获得性肺炎(hospital acquired pneumonia, HAP)诊断及预后评估的价值。方法 选取2015 年7 月—2018 年4 月我院ICU 收治的144 例患者为研究对象,根据在入住ICU 期间是否发生HAP 分为HAP 组(79 例)与 非HAP 组(65 例),对比2 组患者ApoE、PCT 及BNP 水平。根据肺炎严重指数(pneumonia severity index, PSI)评分将 79 例HAP 患者分为低危组、中危组及高危组;根据HAP 患者30 d 存活情况分为存活组与死亡组,然后对不同病情程度、 不同预后患者的ApoE、PCT及BNP 水平进行对比。结果 HAP组的ApoE、PCT及BNP 水平显著高于非HAP组(P 均< 0.05); 不同病情程度HAP 患者之间ApoE、PCT、BNP 水平及PSI 评分对比存在显著差异(P 均< 0.05),其中高危组高于中危组 与低危组,中危组高于低危组;死亡组的ApoE、PCT 及BNP 水平显著高于存活组(P 均< 0.05)。结论 ApoE、PCT 及 BNP 在HAP 患者中的水平高于非HAP 患者,且随着患者病情的加重而升高,对HAP 患者的病情判断及预后评估具有一定 的参考价值。  
Abstract:
Objective To investigate the significance of serum apolipoprotein E (ApoE), procalcitonin (PCT) and brain natriuretic peptide (BNP) in the diagnosis and prognosis of hospital acquired pneumonia (HAP). Methods One hundred and forty-four patients who were treated in intensive care unit of our hospital from July 2015 to April 2018 were selected as study objects. According to the occurrence of HAP during ICU stay, the included patients were divided into HAP group (79 cases) and non-HAP group (65 cases). ApoE, PCT and BNP levels between the 2 groups were compared. According to the pneumonia severity index (PSI) score, 79 HAP patients were divided into low-risk group, middle-risk group and high-risk group. According to the 30-day survival, the HAP patients were divided into survival group and death group. Then the levels of ApoE, PCT and BNP in patients with different severity and different prognosis were compared. Results The levels of ApoE, PCT and BNP in HAP group were significantly higher than those in non-HAP group (P < 0.05). There were significant differences in ApoE, PCT, BNP levels and PSI score in HAP patients with different severities (P < 0.05), and the high-risk group was higher than the middle-risk group and the low-risk group, and the middle-risk group was higher than the low-risk group (P < 0.05). The levels of ApoE, PCT and BNP in the death group were significantly higher than those in the survival group (P < 0.05). Conclusions The levels of ApoE, PCT and BNP in HAP patients are higher than those in non- HAP patients. The levels increase along with the severity of the disease. They have certain reference value in judging the condition and evaluating the prognosis of HAP patients.

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备注/Memo

备注/Memo:
[ 基金项目] 邯郸市科学技术研究与发展计划项目(1423108126)
[ 通信作者] 邢琳琳,E-mail: xinxinqing33@163.com
*Corresponding author, E-mail: xinxinqing33@163.com
更新日期/Last Update: 2019-05-15