|本期目录/Table of Contents|

[1]王亚东.乙型肝炎孕妇HBV 血清标志物与HBV DNA 载量及ALT 的相关性分析[J].传染病信息,2019,03:233-235.
 WANG Ya-dong*.Correlation of serum markers of HBV with HBV DNA load and ALT in HBV infected pregnant women[J].Infectious Disease Information,2019,03:233-235.
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乙型肝炎孕妇HBV 血清标志物与HBV DNA 载量及ALT 的相关性分析(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2019年03期
页码:
233-235
栏目:
论 著
出版日期:
2019-07-12

文章信息/Info

Title:
Correlation of serum markers of HBV with HBV DNA load and ALT in HBV infected pregnant women
文章编号:
   1007-8134(2019)03-0233-03
作者:
王亚东
266200,青岛市即墨区卫生和计划生育局城区疾病预防控制工作站通济卫生防保站(王亚东)
Author(s):
WANG Ya-dong*
Tongji Health Prevention Station, Urban Disease Prevention and Control Workstation, Jimo District Health and Family Planning Bureau of Qingdao, 266200, China
关键词:
乙型肝炎孕妇 HBV血清标志物HBV DNA载量ALT
Keywords:
pregnant women with hepatitis B HBV serum marker HBV DNA load ALT
分类号:
R373.21    
DOI:
10.3969/j.issn.1007-8134.2019.03.009
文献标识码:
A
摘要:
目的 分析乙型肝炎(乙肝)孕妇 HBV血清标志物、HBV DNA载量及 ALT检测结果,为 HBV感染孕妇的诊治提供参考。方法 回顾性分析 2016年 11月—2017年 11月在我区孕检的 120例乙肝孕妇的临床资料,应用酶联免疫吸附法检测血清五项 HBV标志物,同时采用荧光实时定量 PCR技术检测 HBV DNA水平,酶速率法检测 ALT,并对检测结果进行统计分析。结果 120例孕妇血清中,感染模式Ⅰ(大三阳)HBsAg(+)、HBeAg(+)、HBcAb(+)58例,占48.33%;HBV DNA(+)49例,占84.48%,其中 HBV DNA> 106IU/ml 42例,占72.41%;ALT增高 39例,异常率为67.24%。感染模式Ⅱ(小三阳)HBsAg(+)、HBeAb(+)、HBcAb(+)45例,占37.50%;HBV DNA(+)27例,占60.00%,其中 HBV DNA> 106 IU/ml 15例,占 33.33%;ALT增高 20例,异常率为44.44%。感染模式Ⅰ孕妇 HBV DNA阳性率、 HBV DNA> 106 IU/ml率和 ALT异常率最高,感染模式Ⅱ孕妇次之。结论 HBV血清标志物与 HBV DNA高载量和 ALT水平密切相关,三者相结合能为孕妇的临床诊断、围产期干预措施以及疗效观察提供参考依据。    
Abstract:
Objective To analyze the detection results of HBV serum markers, HBV DNA load and ALT levels in pregnantwomen with hepatitis B, and provide evidence for the diagnosis and treatment of HBV infected pregnant women. Methods One hundred and twenty pregnant women with hepatitis B who received a pregnancy test in our district from November 2016 to November 2017 were selected for a retrospective analysis of their clinical information. Five HBV serum markers were detected by enzyme-linked immunosorbent assay. HBV DNA levels were detected by fluorescence real-time quantitative PCR and ALT was detected by enzyme rate assay. All detection results were statistically analyzed. Results In the serum of 120 pregnant women, infection pattern I,that is HBsAg (+), HBeAg (+), HBcAb (+), was found in 58 cases, accounting for 48.33%; 49 cases were HBV DNA (+), accounting for 84.48%, of which HBV DNA> 106 IU/ml in 42 cases, accounting for 72.41%; ALT increased in 39 cases, and the abnormal rate was 67.24%. Infection pattern II, that is HBsAg (+), HBeAb (+), HBcAb (+), was found in 45 cases, accounting for 37.50%; 27 cases were HBV DNA (+), accounting for 60.00%, of which HBV DNA> 106 IU/ml in 15 cases, accounting for 33.33%; ALT increased in 20 cases, and the abnormal rate was 44.44%; The positive rate of HBV DNA, the rate of HBV DNA> 106 IU/ml and the abnormal increase rate of ALT were the highest in pregnant women with infection pattern I, followed by in those with infection pattern II. Conclusions HBV serum markers are closely related to high HBV DNA load and ALT levels. The combination of these 3 indexes can provide a reference forperinatal interventions of pregnant women.       

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备注/Memo

备注/Memo:

[作者单位] 266200,青岛市即墨区卫生和计划生育局城区疾病预防控制工作站通济卫生防保站(王亚东)
[通信作者] 王亚东,E-mail: jimowangyadong@126.com
更新日期/Last Update: 2019-07-12