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[1]陈 皋,刘飞飞,庄 汉,等.国产氟康唑和进口氟康唑对艾滋病合并念珠菌感染的抗菌疗效及免疫功能分析[J].传染病信息,2019,03:236-238251.
 CHEN Gao*,LIU Fei-fei,ZHUANG Han,et al.Antibacterial efficacy and immune function of domestic and imported fluconazole in treatment of AIDS complicated with Candida infection[J].Infectious Disease Information,2019,03:236-238251.
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国产氟康唑和进口氟康唑对艾滋病合并念珠菌感染的抗菌疗效及免疫功能分析(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2019年03期
页码:
236-238251
栏目:
论 著
出版日期:
2019-07-12

文章信息/Info

Title:
Antibacterial efficacy and immune function of domestic and imported fluconazole in treatment of AIDS complicated with Candida infection
文章编号:
   1007-8134(2019)03-0236-04
作者:
陈 皋刘飞飞庄 汉刘 丽刘建英刘舒舒吴孟征秦春俊
618000,德阳市人民医院感染科(陈皋、刘飞飞、庄汉、刘丽、刘建英、刘舒舒、吴孟征、秦春俊)
Author(s):
CHEN Gao* LIU Fei-fei ZHUANG Han LIU Li LIU Jian-ying LIU Shu-shu WU Meng-zheng QIN Chun-jun
Department of Infectious Diseases, Deyang People’s Hospital, 618000, China
关键词:
艾滋病念珠菌感染氟康唑免疫功能  
Keywords:
AIDS Candida infection fluconazole immune function
分类号:
R512.91;R519    
DOI:
10.3969/j.issn.1007-8134.2019.03.010
文献标识码:
A
摘要:
目的 探讨国产氟康唑和进口氟康唑对艾滋病合并念珠菌感染的抗菌疗效及免疫功能的影响。方法 选取 2013年 1月—2018年 4月我院收治确诊的 488例艾滋病合并念珠菌感染患者作为研究对象,通过随机数字表法分为对照组与观察组,病原菌培养类型均为念珠菌。在常规治疗基础上,对照组给予国产氟康唑治疗,观察组给予进口氟康唑治疗,均连续治疗 15 d。比较 2组抗菌疗效、不同时间点 CD4+ T淋巴细胞计数的变化及治疗期间不良反应的发生情况。结果 对照组与观察组各入组 244例患者,其中对照组有 4例因自身原因退出研究。治疗后,观察组抗菌临床疗效总有效率为 72.95%(178/244),明显高于对照组的 64.17%(154/240)(P< 0.05);2组 CD4+ T淋巴细胞计数较治疗前均有显著升高( P< 0.05),且观察组治疗后 10 d、20 d时 CD4+ T淋巴细胞计数均明显高于对照组,差异具有统计学意义( P均< 0.05);治疗期间,观察组不良反应总发生率为 15.98%(39/244),明显低于对照组的 24.17%(58/240)(P< 0.05)。结论 进口氟康唑对艾滋病合并念珠菌感染的抗菌疗效显著,有助于改善患者免疫功能,且不良反应少,安全性高。  
Abstract:
Objective To study the antibacterial efficacy of domestic and imported fluconazole in treatment of AIDS complicated with Candida infection and its effect on immune function. Methods Four hundred and eighty-eight patients of AIDS complicated with Candida infection who were diagnosed and treated in our hospital from January 2013 to April 2018 were selected as research objects. The included patients were divided into control group and observation group according to random digital table method. The pathogenic bacteria culture type was the Candida. On the basis of routine treatment, the control group was treated with domestic fluconazole, while the observation group was treated with imported fluconazole for 15 days. The antibacterial efficacy, the changes of CD4+ T lymphocyte count at different time points and the incidence of adverse reactions during treatment in the 2 groups were compared. Results There were 244 patients enrolled in each of control group and observation group, of which 4 patients in the control group withdrew from thestudy due to personal reason. After treatment, the overall response rate of antibacterial efficacy in the observation group was 72.95%(178/244), which was significantly higher than that of the control group 64.17% (154/240) (P< 0.05). The CD4+ T lymphocyte count of the 2 groups increased significantly compared with that before treatment (P< 0.05), and the CD4+ T lymphocyte count in the observationgroup was significantly higher than that of the control group at 10 days and 20 days after treatment, the difference was statisticallysignificant (P< 0.05). During treatment, the total incidence of adverse reactions in the observation group was 15.98% (39/244), which was significantly lower than that in the control group 24.17% (58/240) (P< 0.05). Conclusions Imported fluconazole has a significant antimicrobial efficacy in the treatment of AIDS complicated with Candida infection, and is conducive to improving immune function, with fewer adverse reactions and high safety.       

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备注/Memo

备注/Memo:

[作者单位] 618000,德阳市人民医院感染科(陈皋、刘飞飞、庄汉、刘丽、刘建英、刘舒舒、吴孟征、秦春俊)
[通信作者] 陈皋,E-mail: 494848467@qq.com
更新日期/Last Update: 2019-07-12