|本期目录/Table of Contents|

[1]王芳,郭晶晶,向攀,等.AIDS 并发非结核分枝杆菌感染的临床分析[J].传染病信息,2017,06:331-334.
 WANG Fang,GUO Jing-jing,XIANG Pan,et al.Clinical features of AIDS patients with Nontuberculous mycobacteria infection[J].Infectious Disease Information,2017,06:331-334.
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AIDS 并发非结核分枝杆菌感染的临床分析(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2017年06期
页码:
331-334
栏目:
专题论著
出版日期:
2017-12-20

文章信息/Info

Title:
Clinical features of AIDS patients with Nontuberculous mycobacteria infection
作者:
王芳郭晶晶向攀郜桂菊杨涤韩宁肖江倪量梁洪远张福杰
100015,首都医科大学附属北京地坛医院感染中心感染病科(王芳、向攀、郜桂菊、杨涤、韩宁、肖江、倪量、梁洪远、张福杰),检验科(郭晶晶)
Author(s):
WANG Fang GUO Jing-jing XIANG Pan GAO Gui-ju YANG Di HAN Ning XIAO JiangNI Liang LIANG Hong-yuan ZHANG Fu-jie*
Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, 100015, China
关键词:
非结核分枝杆菌AIDSCD4+ T 细胞
Keywords:
Nontuberculous mycobacteria AIDS CD4+ T cells
分类号:
R512.91
DOI:
10.3969/j.issn.1007-8134.2017.06.004
文献标识码:
A
摘要:
目的 探讨AIDS 患者合并非结核分枝杆菌(Nontuberculous mycobacteria, NTM)感染的临床特点。方法 选择33 例AIDS 并发NTM 感染患者,分析其临床特点、病变部位、免疫状态等,并与AIDS 并发结核分枝杆菌(Mycobacteriumtuberculosis, MTB)感染患者比较。结果 33 例AIDS 合并NTM 感染者中,CD4+ T 细胞计数的中位数为18 个/μl,HGB(93.8±22.9) g/L,29 例患者(87.9%)出现贫血;单核细胞比例(8.66±5.08)%,16 例(48.5%)单核细胞比例升高;ALB(32.7±5.2)g/L,31 例(93.9%)ALB 降低。播散性NTM 为18 例,占54.5%。病变部位以肺部为主,CT 主要表现为炎症渗出,多发结节影,部位不固定,呈现弥散趋势24 例(72.7%)。与同期培养为MTB 感染者比较,在临床、实验室特点方面差异无统计学意义。结论  AIDS 患者合并NTM 多发生于免疫功能严重低下的情况,易合并贫血及低蛋白血症。NTM 感染的临床特点与MTB 感染不易鉴别。
Abstract:
Objective To discuss the clinical features of AIDS patients with Nontuberculous mycobacteria (NTM) infection. Methods Clinical manifestations, locations, immune statues etc. of 33 AIDS patients with NTM were analyzed, and were compared withthose infected with Mycobacterium tuberculosis (MTB). Results Among 33 NTM infected patients, the median of CD4 count was 18/μL.The hemoglobin was (93.8±22.9) g/L, anemia was found in 29 patients(87.9%). The monocyte percentage was (8.66±5.08)%, rose in 16patients (48.5%). The level of albumin was (32.7±5.2) g/L, declined in 31 patients (93.9%). Eighteen patients (54.5%) were diagnosedwith disseminated NTM disease. Twenty-four patients (72.7%) presented with lesions in lung predominantly. CT showed diffuse nodulesor exudative lesions or consolation. No significantly statistic differences were found between NTM and MTB infected patients in clinical,laboratory features. Conclusions Infection of NTM is an AIDS defined illness secondary to advanced immunosuppression in patientswith AIDS. Both anemia and hypoproteinemia are common complications. Clinical features of NTM are not easily distinguished fromMTB.

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备注/Memo

备注/Memo:
[基金项目] 北京市卫生系统高层次卫生技术人才培养计划(2015-3-105)
[通信作者] 张福杰,E-mail: treatment@chinaaids.cn
更新日期/Last Update: 2017-12-20