|本期目录/Table of Contents|

[1]高苗苗,孙子健,张纪元,等.单核样髓系来源抑制细胞在酒精性肝病进展中的特点研究[J].传染病信息,2018,02:112-115,120.
 GAO Miao-miao,SUN Zi-jian,ZHANG Ji-yuan*,et al.Research on the characteristics of monocytic myeloid derived suppressor cells in the progress of alcoholic liver disease[J].Infectious Disease Information,2018,02:112-115,120.
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单核样髓系来源抑制细胞在酒精性肝病进展中的特点研究(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年02期
页码:
112-115,120
栏目:
专题论著
出版日期:
2018-03-20

文章信息/Info

Title:
Research on the characteristics of monocytic myeloid derived suppressor cells in the progress of alcoholic liver disease
作者:
高苗苗孙子健张纪元邹正升
100039,北京大学三〇二临床医学院非感染性肝病 诊疗与研究中心(高苗苗、孙子健、邹正升),感染病诊疗与研 究中心(张纪元)
Author(s):
GAO Miao-miao SUN Zi-jian ZHANG Ji-yuan* ZOU Zheng-sheng*
Non-infectious Liver Disease Treatment and Research Center, Peking University 302 Clinical Medical School, 100039, China
关键词:
酒精性肝病单核样髓系来源抑制细胞疾病进展
Keywords:
alcoholic liver disease monocytic myeloid derived suppressor cells disease progression
分类号:
R575
DOI:
10.3969/j.issn.1007-8134.2018.02.005
文献标识码:
A
摘要:
目的 调查单核样髓系来源抑制细胞(monocytic myeloid derived suppressor cells, mMDSCs)在酒精性肝病 (alcoholic liver disease, ALD)患者外周血中的特点,探讨其与ALD 进展的关系。方法 采用流式检测技术对79 例ALD 患者和23 例健康对照者外周血中mMDSCs 的频率及其产生精氨酸酶的能力进行调查,并进一步分析mMDSCs 频率与患者 疾病进展及临床指标的相关性。结果 与健康对照相比,ALD 患者外周血mMDSCs 频率显著升高(P < 0.001),且与中 性粒细胞/ 淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)呈弱正相关(r=0.263,P=0.019)。进一步分析发现,ALD 患者精氨酸酶阳性mMDSCs 频率显著高于对照组(P < 0.001),且同样与NLR 呈弱正相关(r=0.305,P=0.015)。结论  ALD 患者外周血mMDSCs 显著增多,且与ALD 进展密切相关。本研究为进一步阐明mMDSCs 在ALD 中的作用机制提供 了研究基础。 
Abstract:
Objective To investigate the characteristics of monocytic myeloid derived suppressor cells (mMDSCs) in peripheral blood of patients with alcoholic liver disease (ALD). Methods Seventy-nine patients with ALD and 23 healthy controls (HCs) were enrolled in the study. The frequency of mMDSCs and arginase+ mMDSCs were detected through FACS. Relationships of mMDSCs frequency with disease progression and clinical indicators were further analyzed. Results mMDSC frequencies in peripheral blood of ALD patients were significantly higher than those in HCs (P < 0.001) and were positively correlated with neutrophil to lymphocyte ratio (r=0.263, P=0.019). Further analysis indicated that arginase+ mMDSCs frequencies significantly increased in ALD patients compared with HCs (P < 0.001) and were also positively correlated with neutrophil to lymphocyte ratio (r=0.305, P=0.015). Conclusions mMDSCs in peripheral blood of ALD patients increase significantly and closely relate with disease progression. The present study provides a basis for elucidating the mechanism of mMDSCs in ALD.  

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备注/Memo

备注/Memo:
[基金项目] 国家自然科学基金面上项目(81670527)
[通信作者] 邹正升,E-mail: zszou302@163.com;张纪元, E-mail: uniquezjy@163.com
更新日期/Last Update: 2018-03-20