|本期目录/Table of Contents|

[1]申力军,丁鹏鹏,韩晶晶,等.肝硬化食管胃底静脉曲张破裂出血后肝静脉压力梯度的影响因素分析[J].传染病信息,2018,02:140-144.
 SHEN Li-jun,DING Peng-peng,HAN Jing-jing,et al.Analysis on influential factors of hepatic venous pressure gradient after esophagogastric variceal bleeding in liver cirrhosis[J].Infectious Disease Information,2018,02:140-144.
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肝硬化食管胃底静脉曲张破裂出血后肝静脉压力梯度的影响因素分析(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年02期
页码:
140-144
栏目:
专题论著
出版日期:
2018-03-20

文章信息/Info

Title:
Analysis on influential factors of hepatic venous pressure gradient after esophagogastric variceal bleeding in liver cirrhosis
作者:
申力军丁鹏鹏韩晶晶祁小宝马宇茗马雪梅吴勤吴立兵楚金东于晓莉毕茜张文辉 金波李捍卫
100039 北京,解放军第三〇二医院肝硬化诊疗 一中心(申力军、丁鹏鹏、韩晶晶、祁小宝、马雪梅、吴勤、 吴立兵、楚金东、于晓莉、毕茜、张文辉、金波、李捍卫), 肝衰竭诊疗与研究中心血液净化科(马宇茗)
Author(s):
SHEN Li-jun DING Peng-peng HAN Jing-jing QI Xiao-bao MA Yu-ming MA Xue-mei WU Qin   WU Li-bing CHU Jin-dong YU Xiao-li BI Qian ZHANG Wen-hui JIN Bo* LI Han-wei
First Liver Cirrhosis Diagnosis and Treatment Center, 302 Military Hospital of China, Beijing 100039, China
关键词:
肝硬化食管胃底静脉曲张破裂出血肝静脉压力梯度影响因素
Keywords:
cirrhosis esophagogastric variceal bleeding hepatic venous pressure gradient influential factors
分类号:
R575.2;R364.13
DOI:
10.3969/j.issn.1007-8134.2018.02.011
文献标识码:
A
摘要:
目的 探讨肝硬化食管胃底静脉曲张破裂出血(esophagogastric variceal bleeding, EVB)后肝静脉压力梯度(hepatic venous pressure gradient, HVPG)的影响因素。 方法 选择2015 年1 月—2017 年7 月在我院诊治的肝硬化EVB 患者178 例, 回顾性分析临床资料与HVPG 的关系。 结果 肝硬化EVB 后HVPG 中位数为16.9 mmHg(1 mmHg=0.133 kPa);病毒性肝 硬化患者HVPG 低于非病毒性肝硬化患者,存在非常见侧支循环(uncommon portosystemic collateral circulations, UPCC)、 EVB 次数> 3 次患者伴有较低HVPG,高血糖、低白蛋白症、贫血及肝细胞癌患者伴有较高HVPG,差异均有统计学 意义(P 均< 0.05);多元线性回归分析显示肝硬化病因、糖化血红蛋白水平、EVB 次数及UPCC 对HVPG 有较 大影响。 结论 肝硬化患者EVB 后HVPG 仍高于正常水平;肝硬化病因、糖化血红蛋白水平、EVB 次数及UPCC 是影响 HVPG 的重要因素。
Abstract:
Objective To explorer the influential factors of hepatic venous pressure gradient (HVPG) after esophagogastric variceal bleeding (EVB) in liver cirrhosis. Methods The medical history and clinical data of 178 patients with liver cirrhosis who underwent EVB and their correlation with HVPG measurement in our hospital from January 2015 to July 2017 were retrospectively analyzed. Results The average HVPG value of liver cirrhosis patients who underwent EVB was 16.9 mmHg (1 mmHg=0.133 kPa). HVPG value of viral cirrhosis patients was lower than that of non-viral cirrhosis patients. Patients who had uncommon portosystemic collateral circulations (UPCC) or underwent EVB for more than 3 times might have lower HVPG, while those who had hyperalycemia, hypoalbuminemia, anemia or hepatocellular carcinoma might have higher HVPG, with significant difference (P < 0.05). Multivariant linear regression analysis showed that etiology of cirrhosis, glycosylated hemoglobin level, times of EVB and UPCC could greatly influence HVPG in liver cirrhosis patients after EVB. Conclusions HVPG value increases in liver cirrhosis patients who underwent EVB, and etiology of cirrhosis, glycosylated hemoglobin level, times of EVB and UPCC are regarded the influential factors of HVPG.

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备注/Memo

备注/Memo:
[基金项目] “十二五”国家科技重大专项艾滋病和病毒性肝 炎等重大传染病防治子课题(2013ZX10002001-001-003); 北京市科技新星项目(Z161100004916170)
[通信作者] 李捍卫,E-mail: lhw@medmail.com.cn; 金波, E-mail: jinbo302@sina.com
更新日期/Last Update: 2018-03-20