|本期目录/Table of Contents|

[1]赵爽,许文,陈威巍,等.CXCR5+CD8+ T 细胞在HIV 感染中的免疫特征及其与疾病进展关系的研究[J].传染病信息,2018,02:149-153,167.
 ZHAO Shuang,XU Wen,CHEN Wei-wei*,et al.Immune characteristics of CXCR5+CD8+ T cells in HIV infection and their correlation with disease progression[J].Infectious Disease Information,2018,02:149-153,167.
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CXCR5+CD8+ T 细胞在HIV 感染中的免疫特征及其与疾病进展关系的研究(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年02期
页码:
149-153,167
栏目:
论著
出版日期:
2018-03-20

文章信息/Info

Title:
Immune characteristics of CXCR5+CD8+ T cells in HIV infection and their correlation with disease progression
作者:
赵爽许文陈威巍赵敏
100039,北京大学三〇二临床医学院(赵爽、许文、 陈威巍、赵敏)
Author(s):
ZHAO Shuang XU Wen CHEN Wei-wei* ZHAO Min*
Peking University 302 Clinical Medical School, 100039, China
关键词:
HIV 感染CXCR5+CD8+ T 细胞CD8+ 滤泡调节T 细胞滤泡细胞毒T 细胞
Keywords:
HIV infection CXCR5+CD8+ T cells CD8+ follicular regulatory T cells follicular cytotoxic T cells
分类号:
R512.91
DOI:
10.3969/j.issn.1007-8134.2018.02.013
文献标识码:
A
摘要:
目的 探讨HIV 感染者外周血CXCR5+CD8+ T 细胞的频率、功能变化及其与病情进展的相关性。方法 收 集40 例HIV 感染者和15 例健康对照者,采用流式细胞分析术检测其外周血CXCR5+CD8+ T 细胞频率及IFN-γ 和IL-10 表达,并分析其与血浆HIV 载量和外周血CD4+ T 细胞计数的相关性。结果 与健康对照组相比,HIV 感染组外周血 CXCR5+CD8+ T 细胞频率上调(P < 0.05),且与外周血CD4+ T 细胞计数呈弱正相关(r=0.349,P=0.027),与血浆HIV 载量呈弱负相关(r=-0.377,P=0.040);HIV 感染者外周血CXCR5+CD8+ T 细胞IFN-γ 表达与血浆HIV 载量呈负相关 (r=-0.514,P=0.002);而CXCR5+CD8+ T 细胞IL-10 的表达在HIV 感染者中明显上调(P < 0.05),与外周血CD4+ T 细胞计数呈弱负相关(r=-0.317,P=0.046),与血浆HIV 载量呈正相关(r=0.670,P=0.002)。结论 HIV 感染者外周 血CXCR5+CD8+ T 细胞频率功能变化与疾病进展密切相关。
Abstract:
Objective To investigate the changes of the frequency and function of CXCR5+CD8+ T cell subsets in peripheral blood of HIV infected patients and their correlation with disease progression. Methods Forty HIV infected patients and 15 health controls were enrolled in this study. The frequency of CXCR5+CD8+ T cells and the levels of IFN-γ and IL-10 expression in peripheral blood were examined by flow cytometry. In addition, the correlation of the frequency and function of CXCR5+CD8+ T cells with peripheral CD4+ T lymphocyte counts and plasma HIV load were further analyzed. Results The frequency of CXCR5+CD8+ T cells increased significantly in patients with HIV infection compared with those of health controls (P < 0.05). In addition, the frequency of this subset in peripheral blood was slightly positively correlated with CD4+ T cell counts (r=0.349, P=0.027), and was slightly negatively correlated with plasma viral load (r=-0.377, P=0.040). The IFN-γ expression level was also negatively correlated with plasma viral load in patients with HIV infection (r=-0.514, P=0.002). While IL-10 expression level was upregulated significantly in CXCR5+CD8+ T cells (P < 0.05) and it was slightly negatively correlated with CD4+ T cell counts (r=-0.317, P=0.046) and positively correlated with plasma viral load (r=0.670, P=0.002) in HIV infected patients. Conclusions The changes of the frequency and function of CXCR5+CD8+ T cells in peripheral blood are closely correlated with the progression of HIV infection.

参考文献/References

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备注/Memo

备注/Memo:
[基金项目] 国家自然科学基金(81471577,81470097)
[通信作者] 赵敏,E-mail: drzhaomin@sina.com; 陈威巍, E-mail: cww302@126.com
更新日期/Last Update: 2018-03-20