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[1]曾永会,黎俊宏.2012—2016 年郴州市无偿献血人群HIV 抗体不确定结果的分析[J].传染病信息,2018,02:154-156.
 ZENG Yong-hui,LI Jun-hong*.Analysis on HIV antibody indeterminate results of voluntary blood donors in Chenzhou from 2012 to 2016[J].Infectious Disease Information,2018,02:154-156.
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2012—2016 年郴州市无偿献血人群HIV 抗体不确定结果的分析(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年02期
页码:
154-156
栏目:
论著
出版日期:
2018-03-20

文章信息/Info

Title:
Analysis on HIV antibody indeterminate results of voluntary blood donors in Chenzhou from 2012 to 2016
作者:
曾永会黎俊宏
423000,郴州市疾病预防控制中心微生物检验科 (曾永会);2 1 3 0 2 2,常州市疾病预防控制中心检测检验中 心(黎俊宏)
Author(s):
ZENG Yong-hui LI Jun-hong*
Microbiology Laboratory Department, Chenzhou Center for Disease Control and Prevention, 423000, China
关键词:
无偿献血人群蛋白质印迹不确定结果
Keywords:
voluntary blood donors western blotting indeterminate results
分类号:
R512.91
DOI:
10.3969/j.issn.1007-8134.2018.02.014
文献标识码:
A
摘要:
目的 分析2012—2016 年郴州市无偿献血人群血液标本HIV 抗体筛查(包括初筛和复检)呈阳性并经蛋白质 印迹实验确证后为不确定结果的血清学特点,为临床安全输血、用血提供依据。方法 对2012 年1 月1 日—2016 年12 月31 日郴州市中心血站筛查为HIV 抗体阳性反应的233 例血液标本进行蛋白质印迹确证实验,分析不确定标本的带型。 结果 233 例标本经过确证实验发现有43 例(18.45%)为阳性,107 例(45.92%)为阴性,83 例(35.62%)为不确定。 在不确定标本中,男54 例(65.06%),女29 例(34.94%);< 20、20 ~ 39、40 ~ 59 岁年龄组不确定标本结果分别为2、 54 和27 例。不确定带型中出现单一和组合条带共9 种,单一带型中以p24 最多,为53 例(63.86%),组合条带中以p17 和p24 居多,为10 例(12.05%)。其中11 例在4 周之后完成了随访复检,结果有4 例不确定样品转为阳性(其中2 例的 带型为p24,1 例为p24 和gp160,1 例为p24 和p66),其余7 例条带无进展。结论 血站送检的标本经确证后阳性率较低; 阴性和不确定标本,可进行核酸检测,或4 周后随访加以确证。
Abstract:
Objectives To analyze the serological characteristics of the HIV antibody indeterminate results of voluntary blood donors' specimens in Chenzhou from 2012 to 2016, which were tested by initial screening and reinspection as positive reaction results and then confirmed by western blotting as indeterminate results, and to provide the basis for clinical safe blood transfusion and blood use. Methods Western blotting was applied to test 233 specimens from Chenzhou Blood Center from January 1, 2012 to December 31, 2016, which were positive reaction results by screening and reinspection, and the belt types of indeterminate specimens were analyzed. Results Among 233 specimens, 43 (18.45%) were positive, 107 (45.92%) were negative, and 83 (35.62%) were indeterminate. Among the HIV antibody indeterminate specimens, there were 54 (65.06%) males and 29 (34.94%) females. There were 2, 54 and 27 cases in the age group of< 20 years, 20-39 years and 40-59 years, respectively. Nine belt types were observed, irrespective of a single and combined indeterminate belt. The single belt type was mainly p24, found in 53 cases (63.86%), while combined belt types were mainly p17 and p24, found in 10 cases (12.05%). Eleven cases completed the follow-ups after 4 weeks, and the indeterminate results in 4 cases turned to be positive, including 2 cases of p24, a case of p24 and gp160, a case of p24 and p66. The remaining 7 cases showed no progression. Conclusions There is a lower positive rate among confirmed specimens of the blood center. The nucleic acid detection or follow-up after 4 weeks can be performed to confirm the negative and indeterminate specimens.

参考文献/References

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备注/Memo

备注/Memo:
[基金项目] 常州市科技支撑计划(CE20165042)
[通信作者] 黎俊宏,E-mail: johnlaijordan@126.com
更新日期/Last Update: 2018-03-20