|本期目录/Table of Contents|

[1]赵青平,陈昱昊,林芳,等.不同阶段肝病患者血栓弹力图与常规凝血检测的一致性研究[J].传染病信息,2018,02:157-160.
 ZHAO Qing-ping,CHEN Yu-hao,LIN Fang,et al.Consistency of thromboelastograph and routine coagulation testing in patients at different stages of liver disease[J].Infectious Disease Information,2018,02:157-160.
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不同阶段肝病患者血栓弹力图与常规凝血检测的一致性研究(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年02期
页码:
157-160
栏目:
论著
出版日期:
2018-03-20

文章信息/Info

Title:
Consistency of thromboelastograph and routine coagulation testing in patients at different stages of liver disease
作者:
赵青平陈昱昊林芳王淑英张杨丽吕晓娜刘佳王璐瑶
100089 北京,空军航空医学研究所附属医院检验科 (赵青平);100039 北京,解放军第三〇二医院输血科(陈昱昊、 王淑英、张杨丽、吕晓娜、刘佳),重症医学中心(林芳); 102200,北京大学国际医院输血科(王璐瑶) 前两位作者对本文有同等贡献,均为第一作者
Author(s):
ZHAO Qing-ping CHEN Yu-hao LIN Fang WANG Shu-ying ZHANG Yang-li L? Xiao-na LIU Jia* WANG Lu-yao
Clinical Laboratory, Affiliated Hospital of the Air Force Institute of Aviation Medicine, Beijing 100089, China ZHAO Qing-ping and CHEN Yu-hao are the first authors who contributed equally to the article
关键词:
血栓弹力图凝血功能一致性分析
Keywords:
thromboelastograph coagulation function consistency analysis
分类号:
R446.11;R575
DOI:
10.3969/j.issn.1007-8134.2018.02.015
文献标识码:
A
摘要:
目的 对不同阶段肝病患者的血栓弹力图(thrombelastograph, TEG)参数R 值和常规凝血功能指标PT 和 APTT 进行对比研究。方法 将2016 年2 月—2017 年1 月解放军第三〇二医院住院患者232 例作为研究对象,其中慢性 肝炎患者41 例,肝硬化代偿期患者69 例,肝硬化失代偿期患者79 例,慢性肝衰竭患者43 例。检测上述各类患者TEG 参 数R 值和常规凝血指标PT、APTT,并对2 种检测方法的检测结果进行对比研究。结果 慢性肝炎患者R 值与PT、APTT 进行一致性分析后,kappa 值分别为-0.135(P > 0.05)、0.105(P > 0.05),一致率分别为34.15% 和60.98%。肝硬化代 偿期患者R 值与PT、APTT 一致性分析后,kappa 值分别为0.175(P < 0.05)、0.038(P > 0.05),一致率均为60.90%。 肝硬化失代偿期患者R 值与PT、APTT 一致性分析后,kappa 值分别为0.023(P > 0.05)、0.038(P > 0.05),一致率分 别为43.04% 和49.37%。慢性肝衰竭患者R 值与PT、APTT 一致性分析,kappa 值均为-0.049(P > 0.05),一致率均为 13.95%。结论 因TEG 是从不同角度检测凝血功能,TEG 检测结果可为评估不同阶段肝病患者凝血因子状态提供更加全面 的依据。
Abstract:
Objective To study the consistency of thromboelastograph (TEG) parameters and routine coagulation parameters (PT, APTT) in patients at different stages of liver disease. Methods A total of 232 inpatients at different stages of liver disease were enrolled from the 302 Military Hospital of China from February 2016 to January 2017, including 41 patients with chronic hepatitis, 69 patients with compensatory cirrhosis, 79 patients with decompensated cirrhosis and 43 patients with chronic liver failure. TEG parameter R time and coagulation parameters (PT, APTT) were tested in all included patients and the results were compared between 2 test methods. Results Consistency analysis results showed that the kappa values of TEG R time with PT and APTT in patients with chronic hepatitis were -0.135 (P > 0.05) and 0.105 (P > 0.05), the consistent rates were 34.15% and 60.98% respectively. For patients with compensatory cirrhosis, the kappa values of TEG R time with PT and APTT were 0.175 (P < 0.05) and 0.038 (P > 0.05), the consistent rates were both 60.9%. For patients with decompensated cirrhosis, the kappa values of TEG R time with PT and APTT were 0.023 (P > 0.05) and 0.038 (P > 0.05), the consistent rate was 43.04% and 49.37%. The kappa values of TEG R time with PT and APTT in patients with chronic liver failure were both -0.049 (P > 0.05), the consistent rate was both 13.95%. Conclusions Because of the difference of detection principle, the results of TEG can provide a more comprehensive basis for evaluating the coagulation factor status of patients at different stages of liver disease compared with routine coagulation testing.

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备注/Memo

备注/Memo:
[基金项目] 首都临床特色应用研究(Z141107002514107)
[通信作者] 刘佳,E-mail: liujia--liujia@163.com
更新日期/Last Update: 2018-03-20