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[1]孙萍,盛家和,许青霞,等.不同型别幽门螺杆菌感染的高血压患者血清中TNF-α、IL-6、IL-8 水平研究[J].传染病信息,2018,02:165-167.
 SUN Ping*,SHENG Jia-he,XU Qing-xia,et al.Serum levels of TNF-α, IL-6 and IL-8 in hypertensive patients with different types of Helicobacter pylori infection[J].Infectious Disease Information,2018,02:165-167.
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不同型别幽门螺杆菌感染的高血压患者血清中TNF-α、IL-6、IL-8 水平研究(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年02期
页码:
165-167
栏目:
论著
出版日期:
2018-03-20

文章信息/Info

Title:
Serum levels of TNF-α, IL-6 and IL-8 in hypertensive patients with different types of Helicobacter pylori infection
作者:
孙萍盛家和许青霞周丽莉洪锡田
450008,郑州大学附属肿瘤医院检验科(孙萍、 盛家和、许青霞、周丽莉、洪锡田)
Author(s):
SUN Ping* SHENG Jia-he XU Qing-xia ZHOU Li-li HONG Xi-tian
Department of Clinical Laboratory, Affiliated Cancer Hospital of Zhengzhou University, 450008, China
关键词:
高血压幽门螺杆菌感染血清炎症因子
Keywords:
hypertension Helicobacter pylori infection serum inflammatory factors
分类号:
R57;R446.5;R544.1
DOI:
10.3969/j.issn.1007-8134.2018.02.017
文献标识码:
A
摘要:
目的 调查高血压患者的幽门螺杆菌(Helicobacter pylori, HP)感染率和细胞毒素相关蛋白A(cytotoxin associated protein, CagA)阳性率,以及感染不同型别HP 的高血压患者血清中TNF-α、IL-6、IL-8 水平。方法 以我院90 例 高血压住院患者(高血压组)及65 例同期体检者(健康对照组)为研究对象,调查HP 感染率,检测HP 类型,并采用酶联 免疫吸附法检测高血压患者血清中TNF-α、IL-6、IL-8 水平,对比不同类型HP 感染的患者血清中TNF-α、IL-6、IL-8 水平。 结果 高血压组HP 感染率为84.4%,明显高于健康对照组的52.3%;高血压组中HP 感染者CagA-IgG 阳性率为80.3%,明 显高于健康对照组中的58.8%,差异均有统计学意义(P 均< 0.05)。高血压组中HP-CagA-IgG(+)患者TNF-α、IL-6、 IL-8 水平明显高于HP-CagA-IgG(-)和HP(-)高血压患者,同时HP-CagA-IgG(-)高血压患者亦高于HP(-)高血压患者, 差异均有统计学意义(P 均< 0.05)。结论 高血压患者有更高的HP 感染率和HP-CagA-IgG(+)阳性率, HP-CagA-IgG(+) 高血压患者分泌IL-6、IL-8、TNF-α 水平更高。HP 感染导致的慢性炎症可能参与了高血压形成的病理生理过程。
Abstract:
Objective To investigate the prevalence of Helicobacter pylori (HP) and positive rate of cytotoxin associated protein (CagA) in hypertensive patients and the levels of TNF-α, IL-6 and IL-8 in serum from different types of HP infected patients. Methods Ninety hypertensive patients hospitalized in our hospital (hypertension group) and 65 healthy examinees at the corresponding period (healthy control group) were included in this study. The infection rate of HP and the type of HP were investigated. The serum levels of TNF-α, IL-6 and IL-8 were detected by enzyme linked immunosorbent assay, and the serum levels of TNF-α, IL-6 and IL-8 in patients with different types of HP infection were compared. Results The infection rate of HP in hypertension group was 84.4%, which was significantly higher than that of healthy control group (52.3%), and the positive rate of CagA-IgG in HP infected patients was 80.3%, which was significantly higher than that of healthy controls (58.8%). The difference was statistically significant between 2 groups(P < 0.05). The levels of TNF-α, IL-6 and IL-8 in HP-CagA-IgG(+) group were significantly higher than those in HP-CagA-IgG(-) group and HP(-) group, and those in HP-CagA-IgG(-) group were also higher than those in HP(-) group, the differences were statistically significant(P < 0.05). Conclusions Hypertension patients have a higher HP infection rate and HP-CagA-IgG(+) positive rate. HP-CagA-IgG positive patients have higher levels of IL-6, IL- 88 and TNF-α. Chronic inflammation induced by HP infection may be involved in th e pathophysiology of hypertension.  

参考文献/References

[1] 王艳军,何冰,李晓东. TNF-α、IL-6、NO 在高血压胰岛 素抵抗患者血浆中的变化及意义[J]. 中国医科大学学报, 2006,35(5):525-526,529.
[2] 苗永国,陈洪涛,侯文华,等. 高血压伴左心室肥厚患者 TNF-α、IL-6、hs-CRP 水平变化及临床意义[J]. 中西医结 合心脑血管病杂志,2015,13(12):1405-1407.
[3] 杨光,王前胜,吕云霞,等. 原发性高血压患者幽门螺杆菌 感染及C- 反应蛋白变化研究[J]. 中华医院感染学杂志, 2016,26(12):2735-2737.
[4] 芦燕玲,潘伟琦. 老年高血压患者幽门螺杆菌感染与新发心 脑血管事件关系的研究[J]. 中华老年心脑血管病杂志, 2015,17(2):130-132.
[5] 邓东波,袁斌. 阿托伐他汀对血脂正常高血压患者血清 TNF-α 和IL-6 的影响[J]. 心血管康复医学杂志,2012, 21(4):403-405.
[6] 中国高血压防治指南修订委员会. 中国高血压防治指南2010 [J]. 中华高血压杂志,2011,19(8):701-703.
[7] 谢传珍,胡小佳,刘飞. 高血压患者中幽门螺杆菌感染引起 胃蛋白酶原改变[J]. 南方医科大学学报,2014,34(8):1220- 1223.
[8] 张华,刘利祥,刘智. 糖尿病合并高血压患者血清 IL-6、 IL-10、TNF-α 水平变化及意义[J]. 山东医药,2015, 55(19):79-80.
[9] 陈晨,朱千里,叶渤之,等. 高血压合并糖尿病前期炎症 因子TNF-α 和IL-6 水平的研究[J]. 心电与循环,2016, 35(3):170-173,180.
[10] 童明宏,孙晨光,贺士平. 幽门螺杆菌感染患者血清IL-8 和 TNF-α 的水平变化及临床意义探讨[J]. 检验医学,2004, 19(2):106-108.
[11] 槐永军,张桂驰,柳惠玲. 幽门螺杆菌感染与原发性高血压及 高血压心脏病的关系[J]. 临床军医杂,2014,42(11):1113- 1114,1121.

备注/Memo

备注/Memo:
[通信作者] 孙萍,E-mail: zhangnian163@126.com
更新日期/Last Update: 2018-03-20