|本期目录/Table of Contents|

[1]何泽玲,曹建彪.热休克蛋白70 在肿瘤射频消融治疗中的作用[J].传染病信息,2018,02:180-184.
 HE Ze-ling,CAO Jian-biao*.Role of heat shock protein 70 in radiofrequency ablation treatment for tumor[J].Infectious Disease Information,2018,02:180-184.
点击复制

热休克蛋白70 在肿瘤射频消融治疗中的作用(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年02期
页码:
180-184
栏目:
综述
出版日期:
2018-03-20

文章信息/Info

Title:
Role of heat shock protein 70 in radiofrequency ablation treatment for tumor
作者:
何泽玲曹建彪
100043,首都医科大学石景山教学医院急诊科(何泽玲);100700 北京,陆军总医院全军肝病中心(曹建彪)
Author(s):
HE Ze-ling CAO Jian-biao*
Emergency Department, Shijingshan Teaching Hospital of Capital Medical College, 100043, China
关键词:
肿瘤热休克蛋白70射频消融术
Keywords:
tumor heat shock protein 70 radiofrequency ablation
分类号:
R735.7
DOI:
10.3969/j.issn.1007-8134.2018.02.021
文献标识码:
A
摘要:
热休克蛋白(heat shock protein, HSP)70 是一类广泛存在于原核细胞和真核细胞中高度保守的蛋白质,具有一 定的分子伴侣作用和疾病特异性。近年来,HSP70 在肿瘤微创治疗领域的作用引起了学者们的高度关注。研究发现,HSP70 在射频消融术(radiofrequency ablation, RFA)治疗肿瘤前后的表达存在差异。它对于肿瘤的诊断、治疗和转归等发挥着极其 重要的作用,但目前对相关机制、调节及影响因素等方面研究较少。本文对HSP70 相关基础研究及其在肿瘤RFA 治疗前后 变化的作用进行综述,以期为临床肿瘤RFA 的应用提供更多的帮助。
Abstract:
Heat shock protein(HSP)70, a highly conserved protein, exists in almost all prokaryotic cells and eukaryotic cells, and has a certain molecular partner function and disease specificity. Its impact on the minimally invasive treatment of tumor has attracted high attention in recent years. The study shows that the expression of HSP70 before and after radiofrequency ablation (RFA) in tumor treatment is different. HSP70 plays an extremely important role in disease diagnosis, treatment and prognosis. But the research on mechanism, regulation and influence factors is still inadequate. In order to provide more helps to the application of RFA. This article summarizes the related basic research on HSP70 and its changes before and after RFA tumor treatment.

参考文献/References

[1] Kampinga HH, Hageman J, Vos MJ, et al. Guidelines for the nomenclature of the human heat shock proteins[J]. Cell Stress Chaperones, 2009, 14(1):105-111.
[2] Stadlbauer V, Lang-Olip I, Leber B, et al. Immunohistochemical and radiological characterization of wound healing in porcine liver after radiofrequency ablation[J]. Histol Histopathol, 2016, 31(1):115-129.
[3] Murphy ME. The HSP70 family and cancer[J]. Carcinogenesis, 2013, 34(6):1181-1188.
[4] Gross C, Hansch D, Gastpar R, et al. Interaction of heat shock protein 70 peptide with NK cells involves the NK receptor CD94[J]. Biol Chem, 2003, 384(2):267-279.
[5] Gross C, Koelch W, DeMaio A, et al. Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B[J]. J Biol Chem, 2003, 278(42):41173-41181.
[6] Zagouri F, Sergentanis TN, Gazouli M, et al. HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study[J]. Mol Biol Rep, 2012, 39(12):10873-10879.
[7] Garg M, Kanojia D, Seth A, et al. Heat-shock protein 70-2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion[J]. Eur J Cancer, 2010, 46(1):207-215.
[8] Singh S, Suri A. Targeting the testis-specific heat-shock protein 70-2 (HSP70-2) reduces cellular growth, migration, and invasion in renal cell carcinoma cells[J]. Tumour Biol, 2014, 35(12):12695-12706.
[9] Mardan-Nik M, Pasdar A, Jamialahmadi K, et al. Association of heat shock protein70-2 (HSP70-2) gene polymorphism with coronary artery disease in an Iranian population[J]. Gene, 2014, 550(2):180-184.
[10] Hrira MY, Chkioua L, Slimani A, et al. Hsp70-2 gene polymorphism: susceptibility implication in Tunisian patients with coronary artery disease[J]. Diagnostic Pathology, 2012, 7(1):88.
[11] Scieglinska D, Piglowski W, Mazurek A, et al. The HspA2 protein localizes in nucleoli and centrosomes of heat shocked cancer cells [J]. J Cell Biochem, 2008, 104(6):2193-2206.
[12] Scieglinska D, Gogler-Piglowska A, Butkiewicz D, et al. HSPA2 is expressed in human tumors and correlates with clinical features in non-small cell lung carcinoma patients[J]. Anticancer Res, 2014, 34(6):2833-2840.
[13] Fu Y, Zhao H, Li XS, et al. Expression of HSPA2 in human hepatocellular carcinoma and its clinical significance[J]. Tumour Biol, 2014, 35(11):11283-11287.
[14] Zhang H, Gao H, Liu C, et al. Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma[J]. Diagn Patho, 2015, 10:13.
[15] Noonan E, Giardina C, Hightower L. Hsp70B' and Hsp72 form a complex in stressed human colon cells and each contributes to cytoprotection[J]. Exp Cell Res , 2008, 314(13):2468-2476.
[16] Su Q, Wang Y, Zhao J, et al. Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population[J]. BMC Gastroenterology, 2015, 15:107-112.
[17] Yang Z, Zhuang L, Szatmary P, et al. Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma[J]. Int J Med Sci, 2015, 12(3):256-263.
[18] Yamagata N, Furuno K, Sonoda M, et al. Stomach cancerderived del223V-226L mutation of the STCH gene causes loss of sensitization to TRAIL-mediated apoptosis[J]. Biochem Biophys Res Commun, 2008, 376(3):499-503.
[19] Aoki M, Yamamoto K, Ohyama S, et al. A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population[J]. Biochem Biophys Res Commun, 2005, 335(2):566-574.
[20] Wan T, Zhou X, Chen G, et al. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant[J]. Blood, 2004, 103(5):1747-1754.
[21] Fang H, Wu Y, Huang X, et al. Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response[J]. J Biol Chem, 2011, 286(35):30393-30400.
[22] Gehrmann M, Cervello M, Montalto G, et al. Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma[J]. Front Immunol, 2014, 5:307-314.
[23] Chuma M, Sakamoto M, Yamazaki K, et al. Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma[J]. Hepatology, 2003, 37(1):198-207.
[24] Di Tommaso L, Franchi G, Park YN, et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis[J]. Hepatology, 2007, 45(3):725-734.
[25] Michils A, Redivo M, Zegers de Beyl V, et al. Increased expression of high but not low molecular weight heat shock proteins in resectable lung carcinoma[J]. Lung Cancer, 2001, 33(1):59-67.
[26] Can?z O , Belenli O, Patiroglu TE. General features of gastric carcinomas and comparison of HSP70 and NK cell immunoreactivity with prognostic factors[J]. Pathol Oncol Res, 2002, 8(4):262-269.
[27] Joo M, Chi JG, Lee H. Expressions of HSP70 and HSP27 in hepatocellular carcinoma[J]. J Korean Med Sci, 2005, 20(5):829-834.
[28] Shin E, Ryu HS, Kim SH, et al. The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma[J]. J Hepatobiliary Pancreat Sci, 2011, 18(4):544-550.
[29] Joly AL, Wettstein G, Mignot G, et al. Dual role of heat shock proteins as regulators of apoptosis and innate immunity[J]. J Innate Immun, 2010, 2(3):238-247.
[30] Xanthoudakis S, Nicholson DW. Heat-shock proteins as death determinants[J]. Nat Cell Biol, 2000, 2(9):E163-E165.
[31] Gabai VL, Yaglom JA, Volloch V, et al. Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death[J]. Mol Cell Biol, 2000, 20(18):6826-6836.
[32] Solazzo SA, Ahmed M, Schor-Bardach R, et al. Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways[J]. Radiology, 2010, 255(1):62- 74.
[33] Yang W, Ahmed M, Elian M, et al. Do liposomal apoptotic enhancers increase tumor coagulation and end-point survival in percutaneous radiofrequency ablation of tumors in a rat tumor model[J]. Radiology, 2010, 257(3):685-696.
[34] Yang WL, Nair DG, Makizumi R, et al. Heat shock protein 70 is induced in mouse human colon tumor xenografts after sublethal radiofrequency ablation[J]. Ann Surg Oncol , 2004, 11(4):399- 406.
[35] Schueller G, Kettenbach J, Sedivy R, et al. Heat shock protein expression induced by percutaneous radiofrequency ablation of hepatocellular carcinoma in vivo[J]. Int J Oncol, 2004, 24(3):609-613.
[36] Bhardwaj N, Dormer J, Ahmad F, et al. Heat shock protein 70 expression following hepatic radiofrequency ablation is affected by adjacent vasculature[J]. J Surg Res, 2012, 173(2):249-257.
[37] Hinz S, Tepel J, Roder C, et al. Profile of serum factors and disseminated tumor cells before and after radiofrequency ablation compared to resection of colorectal liver metastase-a pilot study[J]. Anticancer Res, 2015, 35(5):2961-2967.
[38] Teng LS, Jin KT, Han N, et al. Radiofrequency ablation, heat shock protein 70 and potential anti-tumor immunity in hepatic and pancreatic cancers: a minireview[J]. Hepatobiliary Pancreat Dis Int, 2010, 9(4):361-365.
[39] Haen SP, Gouttefangeas C, Schmidt D, et al. Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation[J]. Cell Stress Chaperones, 2011,16(5):495-504.
[40] Canoz O, Belenli O, Patiroglu TE. General features of gastric carcinomas and comparison of HSP70 and NK cell immunoreactivity with prognostic factors[J]. Pathol Oncol Res, 2002, 8(4):262- 269.
[41] 王艳滨,陈敏华,严昆,等. 原发性肝癌射频治疗后局部 免疫功能的变化及其临床意义[J]. 中国微创外科杂志, 2006,6(10):803-806.
[42] Yang W, Ahmed M, Tasawwar B, et al. Combination radiofrequency (RF) ablation and IV liposomal heat shock protein suppression: reduced tumor growth and increased animal endpoint survival in a small animal tumor model[J]. J Control Release, 2012, 160(2):239-244.
[43] Yang W, Cui M, Lee J, et al. Heat shock protein inhibitor, quercetin, as a novel adjuvant agent to improve radiofrequency ablation-induced tumor destruction and its molecular mechanism [J]. Chin J Cancer Res, 2016, 28(1):19-28.
[44] Yang W, Ahmed M, Tasawwar B, et al. Radiofrequency ablation combined with liposomal quercetin to increase tumour destruction by modulation of heat shock protein production in a small animal model[J]. Int J Hyperthermia, 2011, 27(6):527-538.
[45] 吴孟超,周伟平,刘辉. 肝细胞癌早期诊断与治疗对策新进 展[J]. 传染病信息,2009,22 (2):65-68.
[46] 陈万青,郑荣寿,张思维,等. 2012 年中国恶性肿瘤发病和 死亡分析[J]. 中国肿瘤,2016,25(1):1-8.
[47] Duan XH, Li TF, Zhou GF, et al. Transcatheter arterial embolization combined with radiofrequency ablation activates CD8(+) T-cell infiltration surrounding residual tumors in the rabbit VX2 liver tumors[J]. Onco Targets Ther, 2016, 9:2835-2844.

备注/Memo

备注/Memo:
[基金项目] 吴阶平医学基金会肝病医学部(WJP-LD-2012075A)
[通信作者] 曹建彪,E-mail: caojianbiao@sina.com
更新日期/Last Update: 2018-03-20