|本期目录/Table of Contents|

[1]林瑞钰.干扰素注射液联合四季抗病毒合剂对手足口病的疗效观察[J].传染病信息,2018,04:348-351.
 LIN Rui-yu*.Efficacy of interferon injection combined with Siji antiviral mixture on hand, foot and mouth disease[J].Infectious Disease Information,2018,04:348-351.
点击复制

干扰素注射液联合四季抗病毒合剂对手足口病的疗效观察(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年04期
页码:
348-351
栏目:
论 著
出版日期:
2018-08-30

文章信息/Info

Title:
Efficacy of interferon injection combined with Siji antiviral mixture on hand, foot and mouth disease
作者:
林瑞钰
621000, 绵阳市第三人民医院游仙分院儿科 (林瑞钰)
Author(s):
LIN Rui-yu*
Department of Pediatrics, Youxian Branch of the Third People's Hospital of Mianyang City, 621000, China
关键词:
干扰素四季抗病毒合剂手足口病炎症因子
Keywords:
interferon Siji antiviral mixture hand foot and mouth disease inflammatory factors
分类号:
R725.125.7;R2836;R45
DOI:
10.3969/j.issn.1007-8134.2018.04.012
文献标识码:
A
摘要:
目的 分析干扰素注射液联合四季抗病毒合剂在手足口病治疗中的效果。方法 选取2015 年2 月— 2018 年2 月我院收治的手足口病患儿78 例,根据治疗方法不同分为对照组和观察组。对照组采用肌内注射重组人干扰 素-α1b 注射液治疗,观察组加用四季抗病毒合剂口服治疗,分析2 组患儿治疗后的临床效果。结果 观察组总有效率 为94.87%,对照组为79.49%,观察组总有效率高于对照组,差异有统计学意义(P < 0.05)。观察组退热时间、皮疹 消退时间、口腔疱疹愈合时间、正常饮食时间及血清肠道病毒抗体转阴时间均短于对照组,差异有统计学意义 (P 均< 0.05)。经治疗, 观察组去甲肾上腺素(norepinephrine, NE)、促肾上腺皮质激素(adrenocorticotropic hormone, ACTH)、D - 二聚体、乳酸、CRP、降钙素原、TNF-α 治疗前后差值水平均高于对照组,差异有统计学意义 (P 均< 0.05),但2 组患儿干扰素-γ 差值水平比较,差异无统计学意义(P > 0.05)。结论 干扰素注射液联合口服四 季抗病毒合剂治疗手足口病疗效显著,可降低患儿血清炎症因子、NE、ACTH 水平,加快口腔疱疹的愈合。  
Abstract:
Objective To analyze the efficacy of interferon injection combined with Siji antiviral mixture on hand, foot and mouth disease. Methods A total of 78 children with hand, foot and mouth disease who were admitted to our hospital from February 2015 to February 2018 were retrospectively analyze and divided into control group and observation group according to different treatment methods. The children in the control group were treated with recombinant human interferon α1b injection intramuscularly, and those in the observation group were treated with Siji antiviral mixture orally. The clinical effects of 2 groups were analyzed. Results The overall effective rate was 94.87% in observation group and 79.49% in control group. The overall effective rate of observation group was significantly higher than that in control group (P < 0.05). The defervescence time, deflorescence time, oral herpes healing time, normal diet time and serum enterovirus 71 antibody negative time in the observation group were significantly shorter than those in the control group (P < 0.05). The differences of norepinephrine (NE), adrenocorticotropic hormone (ACTH), D-dimer, lactic acid, C-reactive protein, procalcitonin and TNF-alpha level in the observation group before and after treatment were significantly higher than those in the control group (P < 0.05). However, the difference of IFN-γ level of 2 groups was not statistically significant (P >0.05). Conclusions Interferon injection combined with oral Siji antiviral mixture is effective for the treatment of hand, foot and mouth disease. It can reduce the levels of serum inflammatory factor, NE and ACTH, and accelerate the healing of oral herpes.

参考文献/References


[1] Clause AL, Vanderheyde K, Pieters T. Sécurité de la réintroduction de l'erlotinib à faible posologie après un syndrome main-pied induit par l'erlotinib dans une tumeur de Pancoast-Tobias[J]. Rev Mal Respir, 2014, 31(7):628-631.
[2] Bailey EB, Merriman J, Maughan B, et al. Effect of treatment dose reductions in the setting of hand-foot syndrome on survival outcomes in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor receptor inhibitors[J]. J Oncol Pharm Pract, 2017, 24(3):190-197.
[3] 官升灿,王玉海,黄伟,等. 2 组不同剂量丙种球蛋白治疗重 症手足口病的疗效研究[J]. 传染病信息,2016,29(6):363- 365.
[4] 蔡剑雄,陈亮,王元凤,等. 炎琥宁联合干扰素治疗手足口 病疗效评价的Meta 分析[J]. 中国实验方剂学杂志,2015, 21(11):208-214.
[5] 邱慧明,朱祎宏. 重组人干扰素联合痰热清注射液治疗小 儿重症手足口病的临床研究[J]. 中国临床药理学杂志,2017,33(23):2343-2346.
[6] 杨海英,王明月,张全发,等. 中药辨证与α-1b 干扰素防 治手足口病的临床研究[J]. 南京中医药大学学报,2014, 30(1):30-32.
[7] 张霞,赵梁育,单秋歌,等. 四季抗病毒合剂治疗手足口病 35 例临床观察[J]. 中医临床研究,2014,6(20):49-50.
[8] Li X, Zhang X, Ding J, et al. Comparison between Chinese herbal medicines and conventional therapy in the treatment of severe hand, foot, and mouth disease: a randomized controlled trial[J]. Evid Based Complement Alternat Med, 2014, 24(6):1-7.
[9] He LY, Zhang GL, Yan SY, et al. A double-blind comparative study of Chinese herbal medicine Jinlianqingre Effervescent Tablets in combination with conventional therapy for the treatment of uncomplicated hand, foot, and mouth disease[J]. Eur J Clin Microbiol Infect Dis, 2014, 33(8):1429-1437.
[10] Wen T, Xu W, Liang L, et al. Clinical efficacy of andrographolide sulfonate in the treatment of severe hand, foot, and mouth disease (HFMD) is dependent upon inhibition of neutrophil activation[J]. Phytother Res, 2015, 29(8):1161-1167.
[11] Lilly E, Burke M, Kluger H, et al. Pregabalin for the treatment of painful hand-foot skin reaction associated with dabrafenib[J]. JAMA Dermatol, 2015, 151(1):102-103.
[12] 陈必全,孙子发,李阳,等. 热毒宁与干扰素联合治疗手足 口病患儿的临床疗效[J]. 中华医院感染学杂志,2016, 26(9):2143-2145.
[13] 郑龙,肖会敏,郭伦锋,等. 四季抗病毒合剂联用利巴韦林 对CoxAl6 病毒增殖和感染作用的影响[J]. 医学研究杂志, 2016,45(12):61-65.
[14] 陈烨. 四季抗病毒合剂联合利巴韦林治疗手足口病的临床疗 效观察[J]. 中国临床新医学,2015,8(9):848-850.
[15] 曾伟红,邓代金. 四季抗病毒合剂治疗普通小儿手足口病 的疗效及护理[J]. 中国中医药现代远程教育,2015, 35(23):109-110.

备注/Memo

备注/Memo:
[ 作者单位] 621000, 绵阳市第三人民医院游仙分院儿科 (林瑞钰) [ 通信作者] 林瑞钰,E-mail: 50982453@qq.com
更新日期/Last Update: 2018-09-08