|本期目录/Table of Contents|

[1]黄 坤,于久飞,吴丽丽,等.粒细胞集落刺激因子 治疗慢加急性肝衰竭疗效荟萃分析[J].传染病信息,2018,05:439-442.
 HUANG Kun,YU Jiu-fei,WU Li-li,et al.Effects of granulocyte-colony stimulating factor on acute-on-chronic liver failure: a Meta-analysis[J].Infectious Disease Information,2018,05:439-442.
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粒细胞集落刺激因子 治疗慢加急性肝衰竭疗效荟萃分析(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年05期
页码:
439-442
栏目:
专题论著
出版日期:
2018-10-30

文章信息/Info

Title:
Effects of granulocyte-colony stimulating factor on acute-on-chronic liver failure: a Meta-analysis
作者:
黄 坤于久飞吴丽丽胡瑾华
 100123 北京,民航总医院消化内科(黄坤、于久飞); 100853 北京,解放军总医院南楼消化内科(吴丽丽);100039 北京, 解放军第三○二医院肝衰竭诊疗研究中心(胡瑾华)
Author(s):
HUANG Kun YU Jiu-fei WU Li-li HU Jin-hua*
Department of Gastroenterology, Civil Aviation General Hospital, Beijing 100123, China
关键词:
 粒细胞集落刺激因子慢加急性肝衰竭荟萃分析
Keywords:
 granulocyte-colony stimulating factor acute-on-chronic liver failure Meta-analysis
分类号:
R575.3
DOI:
10.3969/j.issn.1007-8134.2018.05.008
文献标识码:
A
摘要:
目的 评价粒细胞集落刺激因子治疗慢加急性肝衰竭的疗效。方法 计算机检索Cochrane 图书馆(1970— 2018)、EMBASE(1966—2018)、Pubmed(1966—2018)和中国生物医学文献资料库(1978—2018),查找粒细 胞集落刺激因子治疗慢加急性肝衰竭随机对照试验的相关文献。由2 名研究者独立选择文献、提取资料和评估方法学 质量,采用Cochrane 协作网提供的RevMan 5.3 软件进行统计分析。结果 共有3 篇文献,包括201 例患者纳入本研究。 荟萃分析结果显示:与安慰剂/ 空白对照组比较,使用粒细胞集落刺激因子治疗可以有效提高慢加急性肝衰竭患者生存率 (RR=1.72,95%CI:1.25 ~ 2.37,P=0.0009)。结论 粒细胞集落刺激因子可以有效提高慢加急性肝衰竭患者生存率。 
Abstract:
 Objective To evaluate the effect of granulocyte-colony stimulating factor (G-CSF) on acute-on-chronic liver failure (ACLF). Methods The literatures and corresponding references of randomized controlled trials on G-CSF in the treatment of ACLF were searched from Cochrane Library (from 1970 to 2018), EMBASE (from 1966 to 2018), Pubmed (from 1966 to 2018) and China Biology Medicine disc (from 1978 to 2018). Selection of literatures, data extraction and methodological quality assessment were separately performed by 2 researchers. The software RevMan 5.3 of Cochrane Collaboration was used for statistical analysis. Results A total of 3 trails, including 201 patients were enrolled in this study. Meta analysis results showed that G-CSF could effectively improve the survival rate of ACLF patients compared with placebo/blank controls (RR=1.72, 95%CI: 1.25 ~ 2.37, P=0.0009). Conclusions G-CSF can effectively improve the survival rate of ACLF patients.  

参考文献/References


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备注/Memo

备注/Memo:
[ 基金项目] 民航总医院科研基金(2014026)
[ 作者单位] 100123 北京,民航总医院消化内科(黄坤、于久飞); 100853 北京,解放军总医院南楼消化内科(吴丽丽);100039 北京, 解放军第三○二医院肝衰竭诊疗研究中心(胡瑾华)
[ 通信作者 ] 胡瑾华,E-mail: hjh@medmail.com.cn
更新日期/Last Update: 2018-10-30