|本期目录/Table of Contents|

[1]申力军,楚金东,马雪梅,等.血清胱抑素C 诊断乙型肝炎 肝硬化肾功能早期损害的意义[J].传染病信息,2018,05:443-448.
 SHEN Li-jun,CHU Jin-dong,MA Xue-mei,et al.Significance of serum cystatin C level for early diagnosis of renal function impairment in patients with HBV-cirrhosis[J].Infectious Disease Information,2018,05:443-448.
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血清胱抑素C 诊断乙型肝炎 肝硬化肾功能早期损害的意义(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年05期
页码:
443-448
栏目:
专题论著
出版日期:
2018-10-30

文章信息/Info

Title:
Significance of serum cystatin C level for early diagnosis of renal function impairment in patients with HBV-cirrhosis
作者:
申力军楚金东马雪梅金 波马宇茗李 莉闫丽萍迟春生毕 茜刘 博来文辉陈素明吴 勤于晓莉李捍卫辛绍杰
100853 北京,解放军总医院/ 解放军医学院(申力军); 100039 北京,解放军第三〇二医院肝硬化诊疗一中心(申力军、 楚金东、李莉、马雪梅、闫丽萍、迟春生、毕茜、刘博、来文辉、 吴勤、于晓莉、李捍卫、金波),肝衰竭诊疗与研究中心(辛绍杰、 马宇茗),临床检验医学中心(陈素明)
Author(s):
SHEN Li-jun CHU Jin-dong MA Xue-mei JIN Bo MA Yu-ming LI Li YAN Li-ping CHI Chun-sheng BI Qian LIU BoJin-dong MA Xue-mei LAI Wen-hui CHEN Su-ming WU Qin YU Xiao-li LI Han-wei* XIN Shao-jie*
Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing 100842, China First Liver Cirrhosis Diagnosis and Treatment Center, 302 Military Hospital of China, Beijing 100039, China
关键词:
乙型肝炎肝硬化胱抑素C肾功能损害
Keywords:
 hepatitis B cirrhosis Cys C renal function impairment
分类号:
 R512.62
DOI:
10.3969/j.issn.1007-8134.2018.05.009
文献标识码:
A
摘要:
目的 探讨血清胱抑素C(cystatin C, Cys C)对乙型肝炎(乙肝)肝硬化患者肾功能早期损害的诊断 意义。方法 选取2012 年12 月—2017 年7 月于我中心住院诊治的血清CRE < 1.5 mg/dl 的乙肝肝硬化患者552 例,回顾性分 析患者临床资料,绘制血清Cys C 诊断肾功能早期损害的ROC 曲线。结果 血清Cys C 与终末期肝病模型(model of end stage liver disease, MELD)评分呈正相关,与估算肾小球滤过率呈负相关;血清Cys C、MELD 评分及年龄是乙肝肝硬化患者肾功能 早期损害的独立危险因素;绘制ROC 曲线提示血清Cys C 敏感诊断肝硬化患者肾功能早期损害建议值为1.16 mg/L。结论 血 清Cys C 可作为临床上乙肝肝硬化患者肾功能早期损害诊断指标,其诊断效能在乙肝肝硬化不同阶段之间差异无统计学意义。 
Abstract:
 Objective To explore the clinical significance of serum cystatin C (Cys C) level for the HBV-cirrhosis patients with early renal function impairment. Methods Five hundred and fifty-two patients with HBV-cirrhosis whose serum creatinine level was lower than 1.5 mg/dl, were enrolled from our center from December 2012 to July 2017. Their clinical characteristics were retrospectively analyzed. The ROC curves of serum Cys C level for early diagnosis of renal function impairment were plotted. Results The serum Cys C was positively correlated with model for end-stage liver disease (MELD) score, and negatively correlated with estimated glomerular filtration rate. The serum Cys C, MELD score and age were the independent risk factors of early renal function impairment in patients with HBV-cirrhosis. The cutoff value of serum Cys C level for the early diagnosis of renal function impairment in patients with HBV-cirrhosis was 1.16 mg/L. Conclusions The serum Cys C level can be an effective marker for early diagnosis of renal function impairment in patients with either compensated or decompensated HBV-cirrhosis.  

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备注/Memo

备注/Memo:
[ 基金项目] 解放军第三〇二医院院长创新基金(QNPY2015025); 十二五国家科技重大专项(2013ZX10002001-001-003) [ 作者单位 ] 100853 北京,解放军总医院/ 解放军医学院(申力军); 100039 北京,解放军第三〇二医院肝硬化诊疗一中心(申力军、 楚金东、李莉、马雪梅、闫丽萍、迟春生、毕茜、刘博、来文辉、 吴勤、于晓莉、李捍卫、金波),肝衰竭诊疗与研究中心(辛绍杰、 马宇茗),临床检验医学中心(陈素明)
[ 通信作者 ] 李捍卫,E-mail: lhw@medmail.com.cn;辛绍杰,E-mail: xinshaojie302@163.com
更新日期/Last Update: 2018-10-30