|本期目录/Table of Contents|

[1]刘 敏,鲁雁秋,李奇穗,等.重庆地区123 例静脉注射吸毒的HIV/HCV 共感染者临床特征分析[J].传染病信息,2018,06:525-528.
 LIU Min,LU Yan-qiu,LI Qi-sui,et al.Clinical characteristics of 123 HIV/HCV co-infected cases among intravenous drug users in Chongqing[J].Infectious Disease Information,2018,06:525-528.
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重庆地区123 例静脉注射吸毒的HIV/HCV 共感染者临床特征分析(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年06期
页码:
525-528
栏目:
论 著
出版日期:
2018-12-30

文章信息/Info

Title:
Clinical characteristics of 123 HIV/HCV co-infected cases among intravenous drug users in Chongqing
作者:
刘 敏鲁雁秋李奇穗何小庆李同心王 静
400036,重庆市公共卫生医疗救治中心感染二科(刘敏、 鲁雁秋、李奇穗、何小庆、李同心、王静)
Author(s):
LIU Min LU Yan-qiu LI Qi-sui HE Xiao-qing LI Tong-xin WANG Jing*
Second Department of Communicable Diseases, Chongqing Public Health Medical Center, 400036, China
关键词:
人类免疫缺陷病毒丙型肝炎病毒合并感染静脉注射吸毒
Keywords:
HIV HCV co-infection intravenous drug abuse 
分类号:
R512.63;R512.91
DOI:
10.3969/j.issn.1007-8134.2018.06.007
文献标识码:
A
摘要:
目的 了解重庆地区静脉注射吸毒(吸毒)的HIV 感染者合并HCV 感染发生率及临床特征,探讨吸毒对 HIV/HCV 共感染者病情的影响。方法 收集吸毒的HIV/HCV 共感染者资料,了解其肝功能及血常规情况,分析出现肝功 能异常及贫血的相关因素;分析吸毒对HIV/HCV 共感染者病情的影响。结果 ① 149 例吸毒的HIV 感染者中合并HCV 感染123 例(82.6%),感染的HCV 中以基因3 型最常见(69.0%);87.0% 的HIV/HCV 共感染者合并其他病原菌感染, 其中结核分枝杆菌最常见(56.1%);14.6% 的HIV/HCV 共感染者规律抗HIV 治疗,8.1% 抗HCV 治疗,短期存活率为 56.1%。②吸毒的HIV/HCV 共感染者中有67.5% 和72.4% 的患者分别伴肝功能异常和贫血,贫血组中女性所占比例较非贫 血组高,CD4+ T 细胞计数较非贫血组低,HIV RNA 定量较非贫血组高(P 均< 0.05)。③有吸毒史的HIV/HCV 共感染者与无吸毒史的HIV/HCV 共感染者比较,前者HGB、ALB 指标降低更明显,后者肝功能异常程度更重(P 均< 0.05)。 结论 重庆地区吸毒的HIV 感染者合并HCV 感染率高,以HCV 基因3 型最常见;该类患者易合并结核菌感染,易出现肝 功能异常及贫血现象,治疗依从性差,病死率高;贫血与性别、CD4+ T 细胞计数、HIV RNA 定量存在相关性;有吸毒史的 HIV/HCV 共感染者营养状况较非吸毒患者差。 
Abstract:
Objective To explore the incidence and clinical characteristics of HCV/HIV co-infected patients in intravenous drug users in Chongqing, and the effect of drug use on HIV/HCV co-infection. Methods Clinical data of HIV/HCV co-infected patients with drug abuse were retrospectively analyzed, to understand the situation of liver function and blood routine, investigate the influential factors of liver dysfunction and anemia, and analyze the influence of drug abuse on the disease condition of HIV/HCV coinfected patients. Results Among the 149 HIV infected cases, 123 cases had combined HCV infection (82.6%). The most common type was gene 3 (69.0%). Among HIV/HCV co-infection patients 87.0% were accompanied with other pathogens, mycobacterium tuberculosis was the most common (56.1%), 14.6% of HIV/HCV co-infection received regular anti-HIV treatment, 8.1% received anti-HCV treatment and the short-term survival rate was 56.1%. Among the HIV/HCV co-infected patients, 67.5% and 72.4% of the patients had liver dysfunction and anemia, respectively. The proportion of women in the anemia group was higher than that in the non-anemia group, and the CD4+ T cell count was lower, while the HIV-RNA level was higher than that in the non-anemia group (P < 0.05). Compared with HIV/HCV co-infected patients without the history of drug abuse, those HIV/HCV co-infected patients with a history of drug abuse showed obviously decreased HGB and ALB, and severe abnormal liver function (P < 0.05). Conclusions HIV/HCV co-infection rate is very high among drug users in Chongqing area. The most common type is HCV gene type 3. These patient is susceptible to tuberculosis infection, liver dysfunction and anemia, with a poor treatment compliance and high mortality. Anemia is related to gender, CD4+ T cell count, and HIV RNA. Drug abuse can aggravate the HIV/HCV co-infection.

参考文献/References


[1] Meijerink H, Van Crevel R, Van der Ven AJ. Intravenous drug use and the spread of HIV: an international perspective[J]. Ned Tijdschr Geneeskd, 2013, 157(21):A5690.
[2] 吴国辉,陈弘,孟雄,等. 重庆市吸毒人群HCV 和HIV 感染 的流行病学调查[J]. 现代预防医学,2010,37(1):134-136.
[3] 刘红虹,罗生强. 2014 年欧洲肝病学会丙型肝炎治疗指南 推荐意见(2014 年4 月)[J]. 临床肝胆病杂志,2014, 30(6):1-6.
[4] 张之南,沈悌. 血液病诊断及疗效标准[M]. 3 版. 北京:科 学出版社,2007:5-6.
[5] 杨亚婷,闫力婷,陈红,等.《2016 年美国胃肠病学会临床 指南:异常肝生化指标的评估》摘译[J]. 临床肝胆病杂志, 2017,33(4):632-637.
[6] 刘丽君,魏来. 丙型肝炎病毒的流行病学[J]. 传染病信息, 2007,20(5):261-264.
[7] 张乾,潘延凤,平骁功. HCV RNA 载量在慢性丙肝、肝硬化、 肝癌患者中的变化及基因分型[J]. 医药论坛杂志,2014, 35(2):47-49.
[8] 胡志军,丁辉,汪晓军.69 例慢性丙型肝炎患者基因型与肝 功能指标、HCVRNA 及中医证型的相关性分析[J]. 北京中 医药,2012,31(3):166-168.
[9] 温先勇,唐敏,邓正华,等. 中国西南三地HCV 基因型的分 布及临床特征[J]. 中国现代医学杂志,2016,26(23):42-46.
[10] 李伟琴,袁致海,徐光华,等.丙型肝炎基因分型进展及临 床意义[J].世界华人消化杂志,2009,17(6):549-554.
[11] 莉莎,张国强,江洋,等. 湖南省HIV 患者合并感染HBV 及HCV 现状调查及风险因素分析[J]. 中国病毒病杂志, 2011,1(5):358-362.

备注/Memo

备注/Memo:
[ 基金项目 ] 重庆市卫生计生委医学科研项目(2017MSXM119) [ 作者单位 ] 400036,重庆市公共卫生医疗救治中心感染二科(刘敏、 鲁雁秋、李奇穗、何小庆、李同心、王静)
[ 通信作者] 王静,E-mail: 403413860@qq.com
更新日期/Last Update: 2018-12-30