|本期目录/Table of Contents|

[1]金 磊,常文仙,黄 磊,等.1 例HIV-1/HBV 共感染复杂病例抗病毒治疗100 周期间NK 细胞、CD4+ T 细胞及相关指标的变化[J].传染病信息,2018,06:571-574.
 JIN Lei,CHANG Wen-xian,HUANG Lei,et al.Changes of natural killer cells, CD4+ T cells and clinical indexes in one complicated case of HIV-1/HBV co-infection during 100-week antiretroviral therapy[J].Infectious Disease Information,2018,06:571-574.
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1 例HIV-1/HBV 共感染复杂病例抗病毒治疗100 周期间NK 细胞、CD4+ T 细胞及相关指标的变化(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2018年06期
页码:
571-574
栏目:
病例报道
出版日期:
2018-12-30

文章信息/Info

Title:
Changes of natural killer cells, CD4+ T cells and clinical indexes in one complicated case of HIV-1/HBV co-infection during 100-week antiretroviral therapy
作者:
金 磊常文仙黄 磊李 静张纪元王福生
100039 北京,中国人民解放军总医院第五医学中心 感染性疾病诊疗与研究中心(金磊、黄磊、李静、张纪元、王福生); 210003,南京第二人民医院肝病科(常文仙)
Author(s):
JIN Lei CHANG Wen-xian HUANG Lei LI Jing ZHANG JI-yuan WANG Fu-sheng*
Treatment and Research Center for Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
关键词:
人类免疫缺陷病毒乙型肝炎病毒自然杀伤细胞共感染肝损伤乙型肝炎表面抗原
Keywords:
human immunodeficiency virus hepatitis B virus natural killer cells co-infection liver damage hepatitis B surface antigen
分类号:
R512.91;R512.62 
DOI:
10.3969/j.issn.1007-8134.2018.06.019
文献标识码:
A
摘要:
 HBV 合并HIV-1 感染时,HIV-1 感染会增加慢性HBV 感染相关的肝炎、肝硬化和终末期肝病的风险。本文对 1 例HIV-1/HBV 共感染病例进行抗反转录病毒治疗(antiretroviral therapy, ART)并随访100 周,分析了ART 对患者乙型肝 炎相关病毒学及肝功能指标的影响,同时分析了NK 细胞数量的动态变化,并结合相关文献进行回顾分析,为临床防治免疫 导致的HIV-1/HBV 共感染患者肝脏损伤提供借鉴。
Abstract:
HIV-1 co-infection can increase the risks of HBV infection-related hepatitis, hepatic cirrhosis and end-stage liver diseases. This paper reported one HIV-1/HBV co-infected patient undergoing antiretroviral therapy (ART) and 100-week follow-ups, analyzed the effect of ART on indexes for hepatitis B related virology and liver function, as well as dynamic changes of natural killer cell counts. We further retrospectively analyzed relevant literatures, and provided a reference for clinical prevention and treatment of liver damage in HIV-1/HBV co-infected patients.     

参考文献/References


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备注/Memo

备注/Memo:
[ 基金项目] “十三五”国家传染病重大专项(2018ZX10302104-002)
[ 作者单位] 100039 北京,中国人民解放军总医院第五医学中心 感染性疾病诊疗与研究中心(金磊、黄磊、李静、张纪元、王福生); 210003,南京第二人民医院肝病科(常文仙)
[ 通信作者] 王福生,E-mail: fswang302@163.com
更新日期/Last Update: 2018-12-30