|本期目录/Table of Contents|

[1]吴英桂,邱建玲,唐南仲.更昔洛韦与阿昔洛韦治疗水痘临床疗效的对比研究[J].传染病信息,2019,04:338-340.
 WU Ying-gui,QIU Jian-ling,TANG Nan-zhong*.Comparison of clinical efficacy of ganciclovir and acyclovir in the treatment of varicella[J].Infectious Disease Information,2019,04:338-340.
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更昔洛韦与阿昔洛韦治疗水痘临床疗效的对比研究(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2019年04期
页码:
338-340
栏目:
论著
出版日期:
2019-09-12

文章信息/Info

Title:
Comparison of clinical efficacy of ganciclovir and acyclovir in the treatment of varicella
文章编号:
1007-8134(2019)04-0338-03
作者:
吴英桂邱建玲唐南仲
571100,海口市第三人民医院皮肤科(吴英桂、邱建玲);570208,海口市人民医院全科医学科(唐南仲)
Author(s):
WU Ying-gui QIU Jian-ling TANG Nan-zhong*
Department of Dermatology, the Third People’s Hospital of Haikou, 571100, China
*Corresponding author, E-mail: 422969018@qq.com
关键词:
水痘水痘- 带状疱疹病毒更昔洛韦阿昔洛韦
Keywords:
 varicella varicella zoster virus ganciclovir acyclovir
分类号:
 R511.5
DOI:
10.3969/j.issn.1007-8134.2019.04.013
文献标识码:
A
摘要:
目的 对比分析更昔洛韦与阿昔洛韦治疗水痘的临床疗效与安全性。方法 选取2017 年6 月—2018 年6 月我 院收治的110 例水痘患者作为研究对象,按照随机数字表法分为阿昔洛韦组(阿昔组)与更昔洛韦组(更昔组),各55 例。 对比分析 2 组患者临床疗效,临床症状改善时间,不良反应发生情况及用药安全性等。结果 治疗7 d 后,更昔组总有效率 为96.36%,明显高于阿昔组的78.18%,差异有统计学意义(P < 0.05);更昔组水痘- 带状疱疹病毒转阴时间为(1.58±1.01)d, 短于阿昔组的(2.92±1.06)d。此外,更昔组水疱结痂时间、退热时间、疼痛与瘙痒缓解时间也均短于阿昔组,差异均有统 计学意义(P 均< 0.05);更昔组不良反应发生率为3.64%,低于阿昔组14.55% 的不良反应发生率,差异有统计学 意义(P < 0.05)。结论 在临床基础资料均衡的情况下,与阿昔洛韦相比,更昔洛韦治疗水痘临床总有效率更高,患者 水疱结痂时间及临床症状改善时间均更短且治疗安全性更高,不良反应发生率低,具有临床推广价值。 
Abstract:
Objective To compare and analyze clinical efficacy and safety of ganciclovir and acyclovir in treatment of varicella. Methods One hundred and ten varicella patients admitted to our hospital from June 2017 to June 2018 were equally divided into acyclovir group and ganciclovir group according to random number method, with 55 cases in each group. Clinical efficacy, the time of clinical symptoms improvement, the incidence of adverse reactions and the drug safety were compared and analyzed between 2 groups. Results After 7 days of treatment, the total effective rate in ganciclovir group was 96.36%, which was obviously higher than that in acyclovir group (78.18%), and the difference was statistically significant (P < 0.05). The time of varicella zoster virus negative transformation in the ganciclovir group was (1.58±1.01) d, which was shorter than that in the acyclovir group (2.92±1.06) d. Moreover, the time of blister scarring, the antipyretic time, the time of pain and itch relief in the ganciclovir group were significantly shorter than those in the acyclovir group (P < 0.05). The incidence of adverse reactions in the ganciclovir group was 3.64%, which was lower than that in the acyclovir group (14.55%), and the difference was statistically significant (P < 0.05). Conclusions In some case of balanced basic clinical data, ganciclovir has a greater clinical promotion value than acyclovir, due to a higher total effective rate, shorter time of blister scarring and clinical symptoms improvement, higher safety and lower incidence of adverse reaction in the treatment of varicella.    

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备注/Memo

备注/Memo:

[ 通信作者] 唐南仲,E-mail: 422969018@qq.com
更新日期/Last Update: 2019-09-15