|本期目录/Table of Contents|

[1]洪香周,赵大海.血液相关标志物在 社区获得性肺炎病程中的表达及意义[J].传染病信息,2019,04:352-354.
 HONG Xiang-zhou*,ZHAO Da-hai.Expression and significance of blood-related markers in the course of community-acquired pneumonia[J].Infectious Disease Information,2019,04:352-354.
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血液相关标志物在 社区获得性肺炎病程中的表达及意义(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2019年04期
页码:
352-354
栏目:
论著
出版日期:
2019-09-12

文章信息/Info

Title:
Expression and significance of blood-related markers in the course of community-acquired pneumonia
文章编号:
1007-8134(2019)04-0352-03
作者:
洪香周赵大海
2 3 1 5 0 0, 庐江县中医院呼吸内科(洪香周);2 3 1 5 0 0 合肥,安徽医科大学第二附属医院呼吸与危重症科(赵大海)
Author(s):
HONG Xiang-zhou* ZHAO Da-hai
Department of Respiratory Medicine, Traditional Chinese Medicine Hospital of Lujiang County, 231500, China
*Corresponding author, E-mail: well999@126.com
关键词:
社区获得性肺炎CURB-65 评分超敏C 反应蛋白降钙素原红细胞体积分布宽度中性粒细胞淋巴细 胞比值
Keywords:
 community-acquired pneumonia CURB-65 score hyper-sensitive C-reactive protein procalcitonin red blood cell distribution width neutrophil to lymphocyte ratio
分类号:
R563.1
DOI:
10.3969/j.issn.1007-8134.2019.04.018
文献标识码:
A
摘要:
目的 研究社区获得性肺炎(community-acquired pneumonia, CAP)患者治疗过程中血液相关标志物水平,探 讨其在疾病转归中的意义。方法 选取2017 年2 月—2018 年1 月我院收治的76 例CAP 患者作为研究对象,根据CURB-65 评分,将其分为高危组、中危组和低危组,检测患者入院时(24 h 内)及抗感染治疗后5 d 血液中超敏C反应蛋白(hyper-sensitive C-reactive protein, hs-CRP)、降钙素原(procalcitonin, PCT)、红细胞体积分布宽度(red blood cell distribution width, RDW) 以及中性粒细胞淋巴细胞比值(neutrophil to lymphocyte ratio, NLR),比较分析上述指标与CAP 严重程度及疗效的相关性。 结果 入院时,高危组hs-CRP、PCT、RDW和NLR的表达水平分别为(8.82±2.10) mg/L、(14.16±3.46) ng/ml、(16.28±3.46) %、 7.38±1.84,明显高于中危组和低危组(P 均< 0.05);治疗5 d 后,中危组和低危组血液hs-CRP、PCT、RDW 和NLR 水平 逐渐下降,高危组则呈上升趋势(P 均< 0.05);hs-CRP、PCT、RDW 和NLR 与CURB-65 评分均呈正相关(P 均< 0.05)。 结论 血液相关标志物hs-CRP、PCT、RDW 和NLR 均与CAP 严重程度呈正相关,有助于提高临床医生对CAP 患者病情 严重程度判断的准确性。 
Abstract:
Objective To investigate the levels of blood-related markers in patients with community-acquired pneumonia (CAP) during the course of treatment, and to explore its significance in the disease outcome. Methods Seventy-six CAP patients who were admitted in our hospital from February 2017 to January 2018 were included. According to the CURB-65 score, they were divided into high-risk group, middle-risk group and low-risk group. The levels of hyper-sensitive C-reactive protein (hs-CRP), procalcitonin (PCT), red blood cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) were measured at admission (within 24 hours) and after 5-day anti-infection treatment. The correlation of these markers with CAP severity and treatment efficacy was analyzed and compared. Results At admission, the expression levels of hs-CRP, PCT, RDW and NLR in high-risk group were (8.82±2.10) mg/L, (14.16±3.46) ng/ml, (16.28±3.46)%, 7.38±1.84, which were significantly higher than those in middle-risk group and low-risk group (P < 0.05); at 5 days after treatment. The blood levels of hs-CRP, PCT, RDW and NLR in middle-risk group and lowrisk group decreased gradually, while those in high-risk group showed an upward trend (P < 0.05). The hs-CRP, PCT, RDW and NLR were positively correlated with the CURE-65 scores. Conclusions The blood-related markers including hs-CRP, PCT, RDW and NLR are positively correlated with the severity of CAP. This finding will help to improve the accuracy of clinical physician on judging the severity of CAP. 

参考文献/References


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备注/Memo

备注/Memo:
[ 基金项目] 安徽省自然科学基金面上项目(1508085MH192)
[ 通信作者] 洪香周,E-mail: well999@126.com
更新日期/Last Update: 2019-09-15