|本期目录/Table of Contents|

[1]张达利,毕京峰,高银杰,等.肝移植术后患者急性肾损伤危险因素及严重程度分析[J].传染病信息,2019,05:411-414.
 ZHANG Da-li,BI Jing-feng,GAO Yin-jie,et al.Risk factors and severityof acute kidney injury in post-liver transplantation patients[J].Infectious Disease Information,2019,05:411-414.
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肝移植术后患者急性肾损伤危险因素及严重程度分析(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2019年05期
页码:
411-414
栏目:
论著
出版日期:
2019-11-13

文章信息/Info

Title:
Risk factors and severityof acute kidney injury in post-liver transplantation patients
文章编号:
1007-8134(2019)05-0411-04
作者:
张达利毕京峰高银杰贺 希冯丹妮周 霞周双男刘振文刘鸿凌
100039北京,中国人民解放军总医院第五医学中心 肝移植中心(张达利、高银杰、贺希、冯丹妮、周霞、周双男、 刘振文、刘鸿凌),临床研究管理中心(毕京峰)
Author(s):
ZHANG Da-li BI Jing-feng GAO Yin-jie HE Xi FENG Dan-ni ZHOU Xia ZHOU Shuang-nan LIU Zhen-wen LIU Hong-ling*
Liver Transplantation Center, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
关键词:
肝移植急性肾损伤危险因素
Keywords:
liver transplantation acute kidney injury risk factors
分类号:
R657.3;R692
DOI:
10.3969/j.issn.1007-8134.2019.05.007
文献标识码:
A
摘要:
目的分析肝移植术后患者急性肾损伤( acute kidney injury, AKI)的危险因素及 AKI严重程度的影响因素。方法收集 2005年 1月—2015年 8月在我中心进行肝移植手术患者,排除术前 AKI患者,共入组 469例,对该组患者术前、术中、术后影响 AKI的危险因素及术后 4周时的转归进行分析、研究。结果469例患者中,术后发生 AKI者 274例( AKI组)无 AKI者 195例(非 AKI组),发病率为 58.4%。受体身体质量指数( body mass index, BMI)、术前肌酐水平、冷缺血时间、(,)手术时间、下腔静脉阻断时间、术后乳酸峰值、术后 AST峰值等均是发生 AKI的危险因素。术后 4周 AKI组 20.4%患者肾功能仍然异常,病死率为 3.6%,较非 AKI组明显升高( P=0.027)。结论肝移植术后发生 AKI的影响因素较多,受体 BMI、术前肌酐水平、阻断下腔静脉时间、手术时间、术后乳酸峰值、术后 AST峰值均是发生 AKI的独立危险因素。术后 4周 AKI组患者肾功能异常及病死率较非 AKI组均明显升高。
Abstract:
ObjectiveTo evaluate the risk factors of acute kidney injury (AKI) and the influencing factors for the severity ofAKI in post-liver transplantation patients. MethodsThe patients who received a liver transplantation in our center from January2005 to August 2015 were included in this study, while preoperative AKI patients were excluded. A total of 469 patients were enrolled. Risk factors for AKI before, during and after liver transplantation and outcomes at 4 weeks after liver transplantation were analyzedand investigated. ResultsAmong the involved 469 patients, 274 cases appeared AKI (AKI group) and 195 cases had no AKI (non-AKI group) after liver transplantation, the AKI incidence was 58.4%. Risk factors for AKI included recipient’s body mass index (BMI), preoperative creatinine level, cold ischemia time, duration of surgery, duration of inferior vena clamping, postoperative peak lactate and postoperative peak AST. At 4 weeks after liver transplantation, 20.4% of AKI patients still had abnormal renal functions and a mortalityof 3.6%, which were significantly higher than those without AKI (P=0.027). ConclusionsPost-liver transplantation AKI is influenced by several factors. Recipient’s BMI, preoperative creatinine level, duration of inferior vena clamping, duration of surgery, postoperativepeak lactate and postoperative peak AST are the independent risk factors for AKI. At 4 weeks post-liver transplantation, abnormal renal functions and mortality are obviously higher in patients with AKI than patients without AKI.

参考文献/References

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备注/Memo

备注/Memo:
[基金项目]北京市科委项目(Z161100000116058);中国人民 解放军总医院第五医学中心院内课题(YNKT2014006)
[作者单位]100039北京,中国人民解放军总医院第五医学中心 肝移植中心(张达利、高银杰、贺希、冯丹妮、周霞、周双男、 刘振文、刘鸿凌),临床研究管理中心(毕京峰)
[通信作者]刘鸿凌,E-mail:lhl7125@sina.com
*Correspondingauthor,E-mail:lhl7125@sina.com
更新日期/Last Update: 2019-11-13