|本期目录/Table of Contents|

[1]王晓晴,仲亚君,陈 轩.HBV 携带孕妇与正常孕妇雌激素水平及妊娠结局的对比性研究[J].传染病信息,2019,05:428-430+440.
 WANG Xiao-qing*,ZHONG Ya-jun,CHEN Xuan.Comparative study on estrogen level and pregnancy outcomebetween pregnant women with HBV and normal pregnant women[J].Infectious Disease Information,2019,05:428-430+440.
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HBV 携带孕妇与正常孕妇雌激素水平及妊娠结局的对比性研究(PDF)

《传染病信息》[ISSN:1007-8134/CN:11-3886/R]

期数:
2019年05期
页码:
428-430+440
栏目:
论著
出版日期:
2019-11-13

文章信息/Info

Title:
Comparative study on estrogen level and pregnancy outcomebetween pregnant women with HBV and normal pregnant women
文章编号:
1007-8134(2019)05-0428-04
作者:
王晓晴仲亚君陈 轩
 215200,苏州市第九人民医院产科(王晓晴、仲亚君、陈轩)
Author(s):
WANG Xiao-qing* ZHONG Ya-jun CHEN Xuan
Department of Obstetrics, the Ninth People’s Hospital of Suzhou, 215200, China
关键词:
妊娠期 HBV雌激素肝功能妊娠结局
Keywords:
pregnancy HBV estrogen liver function pregnancy outcome
分类号:
R714.251
DOI:
10.3969/j.issn.1007-8134.2019.05.012
文献标识码:
A
摘要:
目的探讨 HBV携带孕妇与正常孕妇雌激素水平及妊娠结局的差异,为临床 HBV携带孕妇正常妊娠提供参考依据。方法选取 2015年 1月—2018年 1月本院收治的 226例孕妇作为研究对象,将其中 116例正常孕妇作为对照组,其余 110例 HBV携带孕妇作为观察组,检测 2组体内雌激素水平,并分析对妊娠结局产生的影响。结果观察组雌酮、雌二醇、雌三醇水平均显著高于对照组( P均< 0.05)。观察组胎儿窘迫、新生儿窒息、剖宫产及早产等妊娠结局的发生率均显著高于对照组,顺产率显著低于对照组( P均< 0.05)。观察组蛋白尿、尿 WBC阳性、妊娠期高血压及产后出血等并发症的发生率均显著高于对照组( P均< 0.05)。Logistic多元回归分析结果显示,雌激素水平高、年龄大、携带 HBV时间长、有既往治疗史、病毒载量高、 ALT水平高均为妊娠不良结局的危险因素( P均< 0.05)。结论HBV携带孕妇机体分泌的雌激素水平显著升高,进一步增加肝脏的负荷,导致肝功能出现明显异常,增加了妊娠不良结局及妊娠并发症的发生率,临床应加强对 HBV携带孕妇相关指标检测,并做好相关并发症的预防。
Abstract:
ObjectiveTo investigate the difference of estrogen level and pregnancy outcome between pregnant women withHBV and normal pregnant women, and provide evidence for clinical pregnancy of pregnant women with HBV. MethodsTwo hundred and twenty-six pregnant women admitted to our hospital from January 2015 to January 2018 were selected as the study objects, 116 of them were normal pregnant women as the control group, the remaining 110 of them were pregnant women with HBV as the observation group. The estrogen levels of pregnant women in 2 groups were detected, and the influence on pregnancy outcome was analyzed. ResultsThe levels of estrone, estradiol, estriol in the observation group were significantly higher than those in the control group (P< 0.05). The incidences of pregnancy outcome such as fetal distress, neonatal asphyxia, cesarean section and premature delivery in the observation group were significantly higher than those in the control group, and the natural birth rate was significantly lower than that in the control group (P< 0.05). The incidences of complication such as proteinuria, positive urine WBC, gestational hypertension and postpartum hemorrhage in the observation group were significantly higher than those in the control group (P< 0.05). Logistic multiple regression analysis showed that high estrogen level, advanced age, long-term course of HBV, previous treatment history, high viral load and high ALT level were all risk factors for adverse pregnancy outcome (P< 0.05). ConclusionsThe level of estrogen secreted by pregnant women with HBV increases greatly. That further increases the load of the liver, leads to obvious abnormality of liver function, and increases incidence of adverse pregnancy outcome and pregnancy complications of pregnant women. In clinical practice, we should strengthen the detection of related indicators for pregnant women with HBV and advocate active prevention of complications.

参考文献/References

[1] 张海燕,于红燕,于建军 . 213例妊娠期合并乙型肝炎病毒携带者病毒感染状况分析[J]. 中国妇幼保健,33(18):4155-4157.
[2] 蒋振林 . 无症状乙型肝炎病毒感染对妊娠肝内胆汁淤积症产妇产后出血及妊娠结局的影响[J]. 中外医学研究,2019, 17(1):127-128.
[3] 任松 . 腺苷蛋氨酸联合糖皮质激素治疗高龄产妇妊娠期肝内胆汁淤积症的疗效及对产妇肝功能指标的影响[J]. 中国妇幼保健,2019,34(2):258-261.
[4] 周顺平 . 还原型谷胱甘肽联合腺苷蛋氨酸及维生素 C片对妊娠期肝内胆汁淤积症患者肝功能及母婴结局的影响[J]. 北方药学,2019,16(1):51-52.
[5] 刘红,吴疆 . 国内外慢性乙型肝炎防治指南比较:抗病毒治疗诊断标准和治疗方案[J]. 中国肝脏病杂志(电子版), 2018,10(1):10-17.
[6] 成军,张玲霞,斯崇文 . 第十次全国病毒性肝炎与肝病学术会议纪要[J]. 传染病信息,2001,13(4):186-188.
[7] 张建宏 . 总胆汁酸水平对妊娠期肝内胆汁淤积症产妇妊娠结局及围生儿的影响[J]. 中国妇幼保健,2018,33(13):2939?2941.
[8] 刘益华,王菲 . 多烯磷脂酰胆碱联合丁二磺酸腺苷蛋氨酸对妊娠期肝内胆汁淤积症患者胆汁酸、肝酶指标及妊娠期结局的影响[J]. 齐齐哈尔医学院学报,2018,39(8):890-892.
[9] 闫琼红,刘波,杨金宇,等 . 妊娠合并乙型肝炎患者血脂及雌激素水平检测的临床意义[J].现代生物医学进展, 2017,17(34):6722-6726.
[10] 赵丹彤,闫惠平 . 自身免疫性肝病抗原抗体研究及临床意义[J]. 传染病信息,2018,31(2):97-100.
[11] 俞忠娜,边佳 . 妊娠期肝内胆汁淤积症患者细胞炎症因子与肝功能的关系及其对妊娠结局的影响[J]. 世界华人消化杂志, 2017,25(27):2469-2474.
[12] 蔡燕红 . 丁二磺酸腺苷蛋氨酸对妊娠期肝内胆汁淤积症患者胆汁酸、肝酶指标及妊娠期结局的影响[J]. 河北医药, 2017,39(8):1155-1157.
[13] 赵志强,庞秋梅,魏宏 . 妊娠合并乙肝病毒感染及病毒携带者对分娩预后的影响[J]. 河北医药,2017,39(16):2496?2498.
[14] 徐英芳,杜洁 . 熊去氧胆酸胶囊治疗胆汁酸正常的妊娠期肝内胆汁淤积症患者的疗效及对妊娠结局的影响[J].中国妇幼保健,2017,32(8):1646-1648.

备注/Memo

备注/Memo:
[基金项目]国家自然科学基金(81293156)
[作者单位]215200,苏州市第九人民医院产科(王晓晴、仲亚君、 陈轩)
[通信作者]王晓晴,E-mail:csr0856@126.com
*Correspondingauthor,E-mail:csr0856@126.com
更新日期/Last Update: 2019-11-13